Early Detection Breakthrough: Biotech Companies Lead the Way in Pancreatic Cancer Treatment
Issued on behalf of
One innovative immunotherapeutic agent, pelareorep, developed by
"We are thrilled to collaborate with GCAR and are honored that pelareorep has been selected as the first therapeutic for evaluation in GCAR's planned adaptive trial in pancreatic cancer patients," said Dr.
Oncolytics is progressing with its lead asset, having recently secured regulatory clearance to evaluate pelareorep in combination with modified FOLFIRINOX (mFOLFIRINOX) +/- Tecentriq® from Roche Holding AG (OTCQX: RHHBY) in newly diagnosed pancreatic cancer patients in a new cohort of its ongoing GOBLET study. This approval follows clearance from German regulatory and ethics bodies. The new cohort is supported by a
Positive outcomes from the pelareorep/mFOLFIRINOX combination could significantly boost Oncolytics' efforts in combating pancreatic cancer. Previously, Oncolytics has shared encouraging data results from the combination of pelareorep with Tecentriq, gemcitabine and nab-paclitaxel. The team at Oncolytics is optimistic that if the mFOLFIRINOX combination shows improved response rates compared to historical control trials, it could advance to a registration-enabling study. This would provide two potential pelareorep-based treatment options for pancreatic cancer patients. Additionally, planned translational research for this cohort will delve deeper into understanding pelareorep's mechanism of action, particularly its effects on the tumor microenvironment (TME).
In this evaluation, Oncolytics will also explore how tumor responses correlate with the expansion of tumor-infiltrating lymphocytes (TILs) in the blood, an effect seen in prior pancreatic cancer studies. The company intends to commence patient enrollment for the mFOLFIRINOX/pelareorep study cohort in Q2 2024.
Roche recently had an investigator-led trial of Tecentriq terminated back in March, while another clinical supply agreement was reached in May to evaluate another Tecentriq combination. Roche is also moving forward with partners BioNTech for a jointly-developed pancreatic cancer vaccine that demonstrated lasting responses in an early trial. In Phase II trials, the mRNA vaccine is administered along with Roche's Tecentriq and chemo against pancreatic cancer.
Now Roche is also working through an agreement with PathAI, a global leader in artificial intelligence AI-powered technology for pathology. Under the terms of the deal, PathAI will work exclusively with
"This collaboration with Roche is a testament to our shared commitment to advancing the field of digital pathology and AI-enabled diagnostics for both drug development and clinical care," said Dr.
Recently the FDA granted priority review to a biologics license application (BLA) from Merus N.V. (NASDAQ: MRUS), seeking the approval of zenocutuzumab (MCLA-128) ("Zeno") for use in the treatment of patients with pancreatic cancer (and NSCLC). The FDA has already granted Breakthrough Therapy Designation (BTD) to Zeno for the treatment of patients with advanced unresectable or metastatic NRG1 fusion-positive pancreatic cancer following progression with prior systemic therapy or who have no satisfactory alternative treatment options.
"FDA acceptance of our first BLA represents an important achievement for Merus and an important potential treatment opportunity for patients with NRG1-positive cancer, a disease with poor prognosis and high unmet need," said
"In preclinical studies, MGC028 demonstrated specific antitumor activity in in-vivo models representing gastric, lung, pancreatic, colorectal, small cell carcinoma, the head and neck, and cholangiocarcinoma," said
Back in February,
"We welcome
Article Source: https://usanewsgroup.com/2023/10/02/the-most-undervalued-oncolytics-company-on-the-nasdaq/
info@usanewsgroup.com
(604) 265-2873
DISCLAIMER:
Nothing in this publication should be considered as personalized financial advice. We are not licensed under securities laws to address your particular financial situation. No communication by our employees to you should be deemed as personalized financial advice. Please consult a licensed financial advisor before making any investment decision. This is a paid advertisement and is neither an offer nor recommendation to buy or sell any security. We hold no investment licenses and are thus neither licensed nor qualified to provide investment advice. The content in this report or email is not provided to any individual with a view toward their individual circumstances.
While all information is believed to be reliable, it is not guaranteed by us to be accurate. Individuals should assume that all information contained in our newsletter is not trustworthy unless verified by their own independent research. Also, because events and circumstances frequently do not occur as expected, there will likely be differences between the any predictions and actual results. Always consult a licensed investment professional before making any investment decision. Be extremely careful, investing in securities carries a high degree of risk; you may likely lose some or all of the investment.
View original content:https://www.prnewswire.com/news-releases/early-detection-breakthrough-biotech-companies-lead-the-way-in-pancreatic-cancer-treatment-302149136.html
SOURCE