Pancreatic Cancer Battle Intensifies: Biotech Innovations Aim to Boost Survival Rates
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Pelareorep, an innovative immunotherapeutic agent developed by
"We are thrilled to collaborate with GCAR and are honored that pelareorep has been selected as the first therapeutic for evaluation in GCAR's planned adaptive trial in pancreatic cancer patients," said Dr.
The research into pelareorep utilizing another chemotherapy backbone, combined with modified FOLFIRINOX (mFOLFIRINOX) +/- Tecentriq® (from Roche), is advancing under Oncolytics' GOBLET study for newly diagnosed pancreatic cancer patients. Following approval from German regulatory and ethics committees, this new cohort has been cleared to begin enrolling patients. Additionally, the
Should the pelareorep/mFOLFIRINOX combination yield favorable results, it could significantly enhance Oncolytics' pancreatic cancer treatment strategies. Oncolytics has already reported promising results from combining pelareorep with Tecentriq, gemcitabine, and nab-paclitaxel. There is optimism within the Oncolytics team that improved response rates from the mFOLFIRINOX combination, compared to historical controls, might pave the way for a registration-enabling study. This development could potentially offer two viable pelareorep-based treatment options for patients with pancreatic cancer. Furthermore, upcoming translational research will focus on exploring pelareorep's mechanism of action, especially its impact on the tumor microenvironment (TME).
Oncolytics will investigate the correlation between tumor responses and the increase of tumor-infiltrating lymphocytes (TILs) in the blood during their evaluation, a phenomenon previously observed in pancreatic cancer studies. The company plans to begin enrolling patients for the mFOLFIRINOX/pelareorep study cohort in the second quarter of 2024.
After announcing positive interim data with notable improvements in estimated median overall survival after experimental treatment,
"Obtaining orphan drug designation marks a significant milestone for Candel, as we continue to develop CAN-2409 for pancreatic cancer," said
Candel's CAN-2409 is the company's most advanced cancer treatment candidate. It uses a specially engineered virus to deliver a specific gene directly into a patient's tumor. This gene triggers a powerful immune response against the cancer. The treatment involves taking a drug called valacyclovir, which the introduced gene converts into a substance that kills cancer cells. This process not only targets the tumor but also helps the immune system recognize and attack the cancer across the body.
The FDA was also recently active in giving accelerated approval for the expanded use of Daiichi Sankyo and
"As the first antibody drug conjugate to be granted a tumor agnostic indication, ENHERTU is truly delivering on its potential across metastatic HER2 targetable tumors," said
On a path to being potentially the first targeted therapy for NRG1+ cancer, Merus N.V. (NASDAQ: MRUS) recently announced the FDA accepted a Biologics License Application (BLA) for priority review for the company's bispecific antibody zenocutuzumab (Zeno) in patients with neuregulin 1 fusion (NRG1+) pancreatic (PDAC) cancer), as well as NRG1+ non-small cell lung cancer (NSCLC).
"FDA acceptance of our first BLA represents an important achievement for Merus and an important potential treatment opportunity for patients with NRG1+ cancer, a disease with poor prognosis and high unmet need," said Dr.
The FDA has already awarded Breakthrough Therapy Designation (BTD) to Zeno for two indications: first, for treating patients with advanced unresectable or metastatic NRG1+ pancreatic cancer who have progressed following prior systemic therapy or who lack satisfactory alternative treatment options, and second, for the treatment of patients with advanced unresectable or metastatic NRG1+ non-small cell lung cancer (NSCLC), following progression with prior systemic therapy.
In an effort to optimize development of the first-in-class drug candidate XCE853,
"To date, our first-in-class metabolic inhibitor, XCE853, has exhibited robust preclinical efficacy in both in vitro and in vivo models across multiple cancer types," said Marc-Henry PITTY, MD, CEO of Oregon Therapeutics. "Lantern's RADR® AI platform will leverage the in vitro and in vivo data to potentially advance XCE853 development in a highly targeted manner and will help inform disease indications and biomarker signatures that can aid in the design of future clinical trials and in the pursuit of combination therapies with other approved cancer drugs."
Oregon Therapeutics has previously performed preclinical studies indicating that in addition to ovarian and pancreatic cancer, XCE853 may also be particularly active in renal, prostate, lung, breast, and head and neck cancers, and leukemia based on preclinical cell-line studies.
Article Source: https://usanewsgroup.com/2023/10/02/the-most-undervalued-oncolytics-company-on-the-nasdaq/
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