Innate Pharma to Present Nectin-4 Antibody Drug Conjugate IPH45 Preclinical Data at AACR 2024
- IPH45 abstract selected for oral presentation at AACR Annual Meeting 2024
- Preclinical data support further development of IPH45, a differentiated topoisomerase I inhibitor ADC targeting Nectin-4, which is progressing towards the clinic
"We are excited to present our findings on IPH45 at this year's AACR. IPH45 is a cutting-edge ADC that delivers a topoisomerase I inhibitor to tumors expressing Nectin-4. Our studies demonstrate that IPH45 effectively inhibits tumor growth both in vitro and in vivo, and it exhibits a favorable safety profile in preclinical studies," stated Prof.
Details of the presentation
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Preclinical characterization of IPH45,
a novel topoisomerase I inhibitor ADC targeting Nectin‑4 for the treatment of Nectin-4 expressing tumors
Abstract Presentation Number: 6582
Session Type: Minisymposium
Session Category: Experimental and Molecular Therapeutics
Session Title: Drug Discovery 2: New Therapies
Session Date/Time:Tuesday Apr 9, 2024 2:30 PM - 4:30 PM
More information can be found on the AACR website.
About IPH45
Nectin-4 is a cell membrane adhesion protein overexpressed in several solid tumors, including urothelial, breast, lung, ovarian, and pancreatic cancers, with limited expression in normal tissues. IPH45 is a novel topoisomerase I inhibitor Antibody Drug Conjugate (ADC) targeting Nectin-4. In non-clinical models, IPH45 is well tolerated and shows anti-tumor efficacy in vitro and in vivo. IPH45 is progressing towards First in Human Studies.
About
Innate’s portfolio includes lead proprietary program lacutamab, developed in advanced form of cutaneous T cell lymphomas and peripheral T cell lymphomas, monalizumab developed with AstraZeneca in non-small cell lung cancer, as well as ANKET® multi-specific NK cell engagers to address multiple tumor types.
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Investors
Tel.: +33 (0)4 84 90 32 88
Henry.wheeler@innate-pharma.fr
Media Relations
NewCap
Arthur Rouillé
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innate@newcap.eu
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