Therapeutic Solutions International Files Patent on “Facilitating Effects” of JadiCells on Gene Therapy Mediated Cell Differentiation
Clinical Stage Company Discloses Unanticipated Synergy Between Mesenchymal Stem Cell Therapy and Genes
In a series of experiments the Company showed that animals made deficient in a hormone producing cells can be treated with great efficacy by combining differentiation promoting gene therapy with JadiCell administration. The observation was made in several models of gene therapy induced cellular differentiation/transdifferentiation and was reproducible with other cells of the mesenchymal stem cell family, although the JadiCell proved the most efficacious.
“We are living in a historic time in which gene therapy has been successfully used to change cells within the body of a patient. For example, insertion of one type of gene can generate blood vessel cells1, another gene can generate cardiac cells2, yet others can generate muscle cells3,” said Dr.
“Therapeutic Solutions International is an ‘Innovation Factory’ that leverages its core expertise in regenerative medicine and immunology to hyper accelerate advancement of new therapeutic approaches from the lab to the patient,” said
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1 McCoy et al. A miRNA cassette reprograms smooth muscle cells into endothelial cells. FASEB J. 2022 Apr;36(4):e22239.
2 Bektik et al. Production of Cardiomyocyte-Like Cells by Fibroblast Reprogramming with Defined Factors. Methods Mol Biol . 2021:2239:33-46.
3 Almeida et al. Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders. J Vis Exp. 2021 Apr 3:(170).
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