Company Announcements

24 September 2020

OptiBiotix Health plc

("OptiBiotix" or the "Company" or the "Group")

Half Year Report

OptiBiotix Health plc (AIM: OPTI), a life sciences business developing compounds to tackle obesity, cardiovascular disease and diabetes, announces its results for the six months ended 30 June 2020.

Highlights

·    First half revenue growth of £744,821, a five times increase in revenues from H1 2019 (2019: £148,818)

·    A 15.5% reduction in other administration costs and a 50% reduction in loss compared to the same period last year

·    A scalable business model delivering a growing number of deals with larger partners, pharmaceutical specialists, and established retailers building brand presence

·    Valuable global intellectual property portfolio of over 70 overlapping patents and 68 trademarks providing strong commercial protection to the group's science and brands

·    Launch of a branded SlimBiome® product range with Holland & Barrett, the first agreement with a major retailer to market our proprietary weight management technology

·    Completion of a successful human study in partnership with Nutrilinea Srl, demonstrating that a new food supplement formulation containing LP_LDL® can reduce high blood pressure (hypertension)

·    The launch in Italy by ALFASIGMA S.p.A. of a food supplement containing the cholesterol reducing LP_LDL® probiotic strain providing an entry into Italy, the largest and fastest growing probiotic market in Europe

·    Extension of the existing terms and territories for our partners CTC Group and Cambridge Commodities for the distribution of SlimBiome®, SlimBiome® Medical and GoFigure

·    The launch of SlimBiome® in the North American market by Agropur

·    An agreement with Optipharm, whose flagship brand Optislim is Australia's leading weight management brand, for the exclusive use of our OptiBiome® weight management ingredient in over 20 countries including Australia, parts of Asia, New Zealand, Middle East, Gulf States and North America

·    The launch of SlimBiome® containing products in Walmart and Costco in the USA and Canada

·    Signing a three-year distribution agreement with a subsidiary of Pierce Group Asia granting it exclusive rights to import and commercialise OptiBiotix's SlimBiome® and LP_LDL® to China and Hong Kong

·    Granting MAXCARE Inc exclusive rights to commercialise OptiBiotix's SlimBiome® proprietary weight management technology in Taiwan

·    Granting Cambridge Commodities Ltd, one of the UK's leading speciality ingredients suppliers, a non-exclusive licence to distribute ProBiotix's specialty ingredient LP_LDL® as well as our finished dietary supplement CholBiome®_x3 for cholesterol and blood pressure reduction in the UK

·    The launch of WellBiome®, a patented supplement to improve gut health, in response to partner interest arising from increased consumer awareness of the human microbiome and the growing trend in health and wellbeing

Post-period end highlights

·    Extension of our existing terms to include the new WellBiome® product with Draco Ingredients GmbH in Germany; Agropur MSI LLC in the USA Canada and Mexico; Maxum Foods in Australia and New Zealand; and CTC Holdings BV in the Philippines, Vietnam, Indonesia, Colombia, the Dominican Republic and Guatemala

·    A non-exclusive distribution agreement with Actial Farmaceutica Srl for the distribution of CholBiome® and CholBiome®_X3 in Australia, New Zealand, Indonesia and Thailand as a product line extension of its VSL^#3® brand

·    Extension of the terms, territories, and products covered by our existing distribution with CTC Holding BV for the sale of CholBiome_X3 to include LP_LDL® as a bulk ingredient and three additional products: CholBiome, CholBiome_BP  and CholBiome_VH,, and to extend coverage from the Philippines to include non-exclusive distribution rights for Vietnam, Indonesia, Colombia, the Dominican Republic and Guatemala

·    Extending the terms of our original exclusive licence agreement for OptiBiome® with OptiPharm Pty Ltd. ("OptiPharm") to include Europe in addition to Australia, parts of Asia, New Zealand, Middle East, Gulf States and North America

·    An exclusive agreement with a US company for the large-scale manufacture and commercialisation of a number of SweetBiotix® products in return for upfront, milestone, launch, and royalty payments

Stephen O'Hara, CEO of OptiBiotix, commented: "This has been another period of exciting progress for OptiBiotix with a 400% increase in sales and a large reduction in costs compared to the same period last year. Our divisions are now making strong progress towards profitability with more agreements generating revenues, existing partners increasing sales, and more retail partners launching successful new products. Our products are now being commercialised with large retail and pharmaceutical partners boosting consumer awareness and confidence in our brands with OptiBiotix now being identified as a key player in the microbiome space within industry.

"The Company is now in a pivotal position of having a scalable business model growing sales from proven products with partners in multiple international territories in the human microbiome market, which is expected to grow at a CAGR of 22.60% between 2020 and 2025*. This presents us with a large and expanding market opportunity on which we are well placed to capitalise by increasing our range of applications, products and territories.

"Whilst uncertainty within the global economic environment will create challenges, we believe that our proven strategy of working with multiple partners, across different application areas and geographies within the healthcare sector, will limit the risk related to any individual deal, product, or geography, and we look forward to continued further progress over the year as a whole."

*Mordor Intelligence 2019

This announcement contains information which, prior to its disclosure, was considered inside information for the purposes of Article 7 of Regulation (EU) No 596/2014 (MAR).

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Caution regarding forward looking statements

Certain statements in this announcement, are, or may be deemed to be, forward looking statements. Forward looking statements are identified by their use of terms and phrases such as ''believe'', ''could'', "should" ''envisage'', ''estimate'', ''intend'', ''may'', ''plan'', ''potentially'', "expect", ''will'' or the negative of those, variations or comparable expressions, including references to assumptions. These forward looking statements are not based on historical facts but rather on the Directors' current expectations and assumptions regarding the Company's future growth, results of operations, performance, future capital and other expenditures (including the amount, nature and sources of funding thereof), competitive advantages, business prospects and opportunities. Such forward looking statements reflect the Directors' current beliefs and assumptions and are based on information currently available to the Directors.

Chairman's and Chief Executive's Statement

We are pleased to present OptiBiotix Health plc's interim results for the six month period ended 30 June 2020.

The first six months of this year has seen strong revenue growth with a 400% increase in group income and individual divisions reporting a 1,309% (SlimBiome®) and 477% (LP_LDL®) increase in revenues. This was achieved against a 15.5% reduction in other administration costs and a 50% reduction in the loss compared to the same period last year. The strong sales growth is especially pleasing given the uncertain global economic environment and impact on potential sales as a result of COVID-19, particularly in countries like India and the USA, in the first six months of the year. Whilst these percentage increases are compared to a low base, there is an acceleration in year-on-year revenue growth as more agreements generate revenues, existing partners grow sales, and more retail partners launch products. The Company is now at a commercial turning point with a proven business model, growing sales from proven products, partners in multiple international territories, and reduced administration and R&D costs. This places the Company in a strong position to exploit the opportunity in the global human microbiome market expected to show a CAGR of 22.60% between 2020 and 2025 (Mordor Intelligence 2019).

Our first generation products, SlimBiome®, and LP_LDL®, are now established scientifically, clinically, and commercially with products being sold in over 120 countries around the world and a growing brand presence. These first generation of products were designed with a low development risk with the aim of establishing the Company and its product positions, and testing the innovative business model in the market. This has now been achieved with the conclusion of multiple deals with large retail and pharmaceutical partners including Alfasigma, Agropur, Holland and Barret, and Optipharm, and OptiBiotix increasingly being identified as a key player in the microbiome space in industry reports (see https://www.openpr.com/news/2004286/what-s-driving-the-human-microbiome-market-size-key-players). Of note is the increasing number of pharmaceutical companies such as Alphasigma and Actial Farmaceutica commercialising LP_LDL® products into the high value GP, hospital, and pharmacy markets. The other significant change in this period was the number of established retailers such as Holland & Barrett, Walmart, and Costco taking products containing SlimBiome®, OptiBiome®, and subsequently WellBiome®, into the mass consumer market. Whilst retail agreements typically have lower margins, they enhance the credibility and consumer awareness of the product, and with it, confidence in the brand. Our products are now increasingly becoming associated with internationally recognised retail and pharmaceutical partners and established brands, which create further interest, and demand in other markets.

The next stage in the Company's development involves: -

·    Achieving and then growing profitability in each division by scaling sales, leveraging our purchasing power as volumes increase to reduce the costs of goods, and focusing on higher margin products and;

·    Commercialising next generation products including microbiome modulators, biotherapeutics, and our growing family of SweetBiotix® products.

As we grow sales and profitability in our first generation products, extend our reach into new application areas and territories, and commercialise next generation products the scale of our opportunity enlarges. 

RESULTS

OptiBiotix results for six months ended June 2020 are set out below. The results are compared with the six months ended 31 May 2019 following the change in our financial year-end from November to December in 2019.

The results show revenue for the six months of £744,821 (2019: £148,818). These figures represent a five times increase in revenues from H1 2019. This increase was achieved despite difficult trading conditions in a number of territories which may have impacted on sales in retail outlets and reduced visits and sale opportunities from partner representatives visiting hospitals, GP's, and pharmacies due to COVID-19 restrictions.

In contrast to 2019 where the majority of this income was generated from LP_LDL®, both the Functional Fibres (SlimBiome®, OptiBiome®, and WellBiome®), and the Probiotics division (LP_LDL®) made roughly equal contributions of £342,734 and £341,858 respectively, with the online store contributing £60,229. As in previous years, there was no substantive contribution from license or royalty payments which tend to be received in the second half of the year, and can greatly influence gross margin. The renegotiation of our contract with Sacco S.r.l., should also help improve margins in H2 2020.

Administrative expenses were £896,268 (2019: £1,025,050) with £162,840 non-cash expenses representing depreciation, amortisation and share based payment charges (2019: £157,112). With increasing revenues and decreasing costs, the loss for the first six months of the year was £605,663, a significant decrease (51%) for the same period last year (2019: £1,217,705).

As at 30 June 2020, the Company had £1.47m Group cash balance. Once R&D tax credits are claimed and recoverable VAT repayments are added, the balance would be £1.68m.

The Company received £746,751 of investment income in this period from the disposal of shares in SkinBioTherapeutics plc.

COMMERCIAL UPDATE

We signed 15 new commercial agreements during the first half: 11 for SlimBiome®, and four for LP_LDL®. Of particular note were deals with Holland and Barrett, Optipharm, and US partners that open up retail opportunities in the UK, Australia, parts of Asia, the Middle East, and North America.  Announcing deals with international recognised partners increases industry awareness of OptiBiotix's brands within the industry, and changes the nature of partner discussions as the commercial benefits are established in more territories.  Growing brand awareness increases the value of a product, and ultimately shareholder value, and is particularly important and valued by large corporates. This is in line with our strategic aim of growing the awareness of ingredient and finished product brands around the world.

LP_LDL®

Sales of LP_LDL® as an ingredient or final product grew by 477% compared to the same period last year. Particularly noteworthy developments in the first half were the successful launch of AlfaSigma's Ezimega 3 product and the commercial growth of Seed Health's Daily Synbiotic. Whilst we consider H2 2020 will be a challenging global economic environment, we believe our strategy of working with multiple partners, across different geographies will help limit any commercial risk.  Post period, the signing of an agreement with Actial Farmaceutica Srl for the distribution of CholBiome® products was a significant achievement and brings further credibility to the LP_LDL® brand. Actial is the developer of one of the world's best-known probiotic brands - VSL#3® - and their products have a reputation for their strong science and clinical studies amongst hospital clinicians, GPs and pharmacists.

We now have partners commercialising LP_LDL® in over 60 countries including the world's largest probiotic market (USA: Seed Health) and second largest (Italy: AlfaSigma). The next stage of our strategy is to grow sales with existing partners, extend territories and applications, and continue to sign up new partners. In addition to growing sales, the Company is renegotiating contracts as volumes increase to reduce the cost of goods. The renegotiation of our contract with Sacco S.r.l., announced in March 2020, from a profit sharing to a manufacture supply agreement where we buy from Sacco and then sell product to partners ourselves, significantly improved margins. The results of this should be seen in H2 2020.

The Company has now published six studies on LP_LDL® in peer reviewed journals or as abstracts at international scientific conferences. These cover the safety and performance of LP_LDL® in human studies, the three mechanisms of action by which LP_LDL® reduces blood lipids, and LP_LDL®'s antimicrobial activity against a wide range of clinically important human and/or animal pathogens including Campylobacter, Shigella, Salmonella, E.coli O157, and Clostridium difficile. The results of two published independent human studies in different countries show significant reductions in both blood pressure and cholesterol and the product to be safe and well tolerated.

Publications and presentations help to differentiate LP_LDL® from products which are sold solely on marketing and reduce the risk of commoditisation and price erosion.  The presence of a scientific and clinical evidence base, GRAS, and pharmaceutical GMP manufacture validation increases the potential for LP_LDL® to be commercialised as a pharmaceutical drug product and are major points of differentiation from other probiotics. Together these designations increase the market attractiveness of LP_LDL® to pharmaceutical partners either used by itself, or as combination treatment to help lower the dose and potential side effects of statins.  This extends the opportunity outside the traditional supplement market into broader therapeutic opportunities which will be explored more actively in H2 2020.

SlimBiome®

Sales of SlimBiome® as an ingredient or final product grew by 1,309% compared to the same period last year. This was largely driven by partners in the UK, Australia and the USA either launching retail products or building stock levels for the launch of products. Of particular note is the extension of SlimBiome® into everyday foods like muesli and porridge and the development of healthy snacks like fruit and fibre gummies under the SnackSmart® brand. The launch of WellBiome® at the end of the period reflects the growing interest from partners in a science backed Health and Wellbeing microbiome product which taps into a global trend for Health & Wellness, a market estimated to be worth US$4.2 trillion in 2019 with the digestive health segment accounting for US$60 billion.

SweetBiotix®

SweetBiotix® is a family of products based on the concept of creating a sweet fibre that has a low glycaemic index, which enhances the microbiome. The concept uses new science, new manufacturing processes, and is a step change from existing products on the market or known to be under development. There are currently around half a dozen types of SweetBiotix® and a couple under development. The aim is to have a broad range of products suitable for a wide range of application areas which meet the needs of multiple partners on applications as diverse as dairy, cereals and hot & cold beverages. The agreement signed post period with a US partner is a significant milestone in the commercialisation of SweetBiotix® products. The agreement, for one part of the SweetBiotix® portfolio, provides an exclusive license in return for the partner bearing all the manufacturing, marketing and commercialisation costs. This is a significant investment for our partner. In return, OptiBiotix will receive upfront, annual and product launch payments from the US partner plus royalties on all future product sales. We have also negotiated enhanced royalty payments on sales of SweetBiotix® products by our partner to 11 application/ innovation partners.

INTELLECTUAL PROPERTY

There has been a rapid increase in the number of patents filed in the microbiome space in the last 10 years, and OptiBiotix and Probiotix Health have together filed over 100 patents to protect their commercial interests and create first mover advantage in this evolving field.  This is being supported by a large investment - typically of over £250,000 year - in patents and trademarks to broaden protection in international markets

Our Intellectual Property ('IP') strategy has been based on building a portfolio of overlapping patents to protect our commercial interests and reduce the risk of any particular patents failing to grant or being opposed by a competitor. This means that we have multiple composition, application, and process patents to protect each area of our business. Whilst this approach is more costly, it reduces our future commercial risk. As patents are granted in key territories (typically the US, Europe, Canada, Japan, Australia, India) the Group is able to reduce its patent portfolio (from 100 to 70 patents) in some territories to lower IP costs whilst continuing to protect its commercial interests.

Our strategy and investment have enabled the Group to build an extensive and valuable intellectual property portfolio of some 70 patents worldwide. In addition to these patents, we have registered over 68 trademarks to provide what is called 'double IP' - a combination of patents and supporting trademarks which allows OptiBiotix to build its trademarked brands supported by its patents.  This approach further reduces risk and in combination creates a valuable IP portfolio in the microbiome field. 

KEY ACHIEVEMENTS

During the period to date we have signed new agreements, had product launches, extended our product range or territories with existing partners, and completed a human study. These achievements continue to build shareholder value, example of which are set out below:-

New agreements

·    Concluding an agreement with Optipharm for the exclusive use of our OptiBiome® weight management ingredient in over 20 countries in its flagship Optislim brand, Australia's leading weight management brand

·    Signing a three-year distribution agreement with a subsidiary of Pierce Group Asia to import and commercialise OptiBiotix's SlimBiome® and LP_LDL® in China and Hong Kong

·    Granting MAXCARE Inc exclusive rights to commercialise OptiBiotix's SlimBiome® proprietary weight management technology in Taiwan

·    The signature of a licensing agreement with Granja Pocha S.A. for the inclusion of ProBiotix's patented probiotic strain LP_LDL® into a functional yogurt product in Uruguay, South America

·    Conclusion of a new licensing agreement with Velinoff Pharma Ltd for the distribution of ProBiotix's products CholBiome® and CholBiome®X3, which contain OptiBiotix's patented LP_LDL® probiotic strain in Bulgaria

·    Reaching a one-year exclusive distribution agreement with Prosperous Pharma, based in Lebanon, to distribute and commercialise OptiBiotix's SlimBiome® Medical to the Gulf Cooperation Council States and the Levant region

Product Launches

·    The launch of a branded SlimBiome® product range with Holland & Barrett, the first agreement with a major retailer to market our proprietary weight management technology

·    The launch in Italy by ALFASIGMA S.p.A. of a food supplement containing our proprietary cholesterol reducing LP_LDL® probiotic strain providing an entry into the largest and fastest growing probiotic market in Europe

·    The launch of SlimBiome® in the North American market by Agropur

·    The introduction of SlimBiome® containing products in Walmart and Costco in the USA and Canada through USA partners Smart For Life and Evolution 18

·    The launch of WellBiome®, a patented supplement to improve gut health; this is a proprietary blend of prebiotic functional fibres, functional dietary fibres and minerals optimised to promote the diversity of the gut microbiome

Extensions of product range or territories with existing partners

·    Signing a new global manufacturing and supply agreement for LP_LDL® with Sacco S.r.l. that changes our original profit-sharing agreement to a manufacture and supply agreement

·    Extension of the existing terms and territories for both CTC Group and Cambridge Commodities for the distribution of SlimBiome®, SlimBiome® Medical and GoFigure

·    Extension of territories with Extensor to distribute GoFigure® consumer weight management products in Ukraine, Estonia, Lithuania, Latvia, Kazakhstan, Kyrgyzstan, Tajikistan, Uzbekistan, Turkmenistan, Armenia, Azerbaijan, Georgia, Belarus, Moldova and Russia 

New Human Studies

·    Completion of a successful human study by ProBiotix Health, in partnership with Nutrilinea Srl, demonstrating that a new food supplement formulation containing LP_LDL® can reduce high blood pressure (hypertension) 

BOARD AND MANAGEMENT

There has been no change to the OptiBiotix Board during the period. As noted in the annual report, Steve Prescott left his position as CEO of our wholly owned subsidiary ProBiotix Health Ltd by mutual agreement at the end of May 2020. Stephen O'Hara is acting as CEO of ProBiotix Health with the support of Mikkel Hvid-Hansen in the expanded role of Commercial Director.

We anticipate that there will be further additions and changes to the Board and management teams as we continue to grow sales and transition to a profitable and sustainable business. Specifically, we expect to enhance our operational and quality control capabilities to meet the needs of our growing list of larger corporate partners and retail customers and add international expertise to support our intention to seek a listing in an international market.

OUTLOOK

The first six months of this year has seen a large increase in sales (400%) as more agreements generate revenues, existing partners grow sales, and more retail partners launch products.  This has been achieved with a 15.5% reduction in other administration costs in a difficult global economic environment. The Company now has proven its business model with established products being sold through an international network of pharmaceutical, ingredient, formulation, and retail partners in over 120 countries around the world, and is identified as a key player in the microbiome space by industry reports. 

The Company remains focused on the next phase of its strategy with each of its divisions currently on course to reach profitability in the current financial year. We anticipate continued revenue growth in 2020 as existing deals contribute to full year revenues, we extend the application of our products into new areas, retail partners launch more products and extend their territories, and we continue to execute deals with new partners. We also anticipate a further reduction in administration costs in the second half of 2020 as management costs are removed from the business and improved gross margins from royalty and license agreements.

To support sales growth, we anticipate adding new products across our portfolio. For LP_LDL® these include more dairy products, and expanding development of our cardiovascular health portfolio with a blood pressure (CholBiomeBP), and vascular health product (CholBiomeVH). This will complete a suite of cardiovascular applications of different formulations which should meet the regulatory and market needs of most countries around the world. We are also exploring further the potential of  LP_LDL®  for its immune health properties after a number of customers have reported reduction in allergies, particularly hay fever, and its use in combination with existing treatments, such as statins, to help lower dose and reduce side effects, whilst maintaining efficacy. We have sequenced LP_LDL®'s genome and are exploring the genetic predisposition of the strain to impact on a range of health areas outside of cardiovascular health.  In addition, we have also been awarded (subject to contract) a grant to explore the effect of LP_LDL® on stress, anxiety, and sleep disorders with universities in the UK and Europe. 

For SlimBiome®, given increased consumer awareness of the human microbiome, and the growing trend in health and wellbeing, we have launched WellBiome®. This uses existing human study data which showed positive effects on the microbiome, mood, and blood pressure. This has allowed us to extend the opportunity outside weight management without adding any development costs by utilising existing studies and changing the dosage in the final product. We have been pleased with the high level of partner interest in WellBiome® as witnessed by the number of agreements signed post period. Investors should also note the number of partners who have gained early success with our products and who are now extending their territories or product range. This has led to the Company continuing to sign new deals and extend existing partner deals as shown by a number of agreements signed post period including:-

·    Extension of our existing terms to include WellBiome® with Draco Ingredients GmbH in Germany; Agropur MSI LLC in the USA Canada and Mexico; Maxum Foods in Australia and New Zealand; and CTC Holdings BV in the Philippines, Vietnam, Indonesia, Colombia, the Dominican Republic and Guatemala

·    A non-exclusive distribution agreement with Actial Farmaceutica Srl for the distribution of CholBiome® and CholBiome®X3 in Australia, New Zealand, Indonesia and Thailand, under the VSL#3® range

·    Extension of the terms, territories, and products with CTC Holding BV for the sale of CholBiomeX3 to include LP_LDL® as a bulk ingredient and three additional products: CholBiome, CholBiomeBP  and CholBiomeVH,, from the Philippines to include non-exclusive distribution rights for Vietnam, Indonesia, Colombia, the Dominican Republic and Guatemala

·    Extending the terms of our original exclusive licence agreement for OptiBiome® with OptiPharm Pty Ltd. ("OptiPharm") to include Europe in addition to Australia, parts of Asia, New Zealand, Middle East, Gulf States and North America

·    An exclusive agreement with a US company for the large-scale manufacture and commercialisation of a number of SweetBiotix® products in return for upfront, milestone, launch, and royalty payments

Having established a range of first generation products (LP_LDL®, SlimBiome®), and a large international network of partners our focus is now turning to commercialising our next generation products with partners. These include our microbiome modulators, biotherapeutics, and the growing family of SweetBiotix® products. The agreement announced post period with a US partner for one part of the SweetBiotix® portfolio is an early example. It provides a 'no cost' route to commercialisation with the partner bearing all the manufacturing, marketing, and commercialisation costs in return for an exclusive worldwide license and milestone and royalty payments.

We believe our strategy of securing deals with partners who make up the value chain (manufacturers, formulators and distributors) across multiple territories is now bearing fruit with rapid revenue growth against a low and decreasing cost base.  The Company is now at a commercial tipping point as its divisions move towards profitability and our global network of partners start to deliver on early forecasts, grow sales, and look to introduce more products into more and more territories.

We continue to explore the potential for a dual international listing in the USA or other international markets. Preparatory work carried out to date includes aligning our financial end of year with similar companies on other international exchanges, reducing our holding in SkinBiotherapeutics plc to reduce the risk of having to include segmental reporting and enhancing our quality and reporting systems. We anticipate further change to the management team and Board and more commercial agreements in the US as we to continue to evolve the Company and build market presence to increase the success of any potential dual listing. 

Investor and consumer interest in the human microbiome is growing, presenting us with a market opportunity that is large and expanding. OptiBiotix is ideally positioned to exploit this opportunity with first generation products which impact on major chronic lifestyle diseases, industry recognition as key industry player in the microbiome space, and next generation products of SweetBiotix® and Microbiome modulators, biotherapeutics, and Medical Devices. We look forward to growing sales as we scale our busines model and strengthen our position in this new and exciting area of science which has the potential to revolutionise the future of healthcare.

We look forward to the future with a stronger team, more deals, more products, and, most importantly, greater revenues and profitability.

On behalf of everyone at OptiBiotix Health we would like to thank our investors for their continued support and look forward to an exciting future.

N Davidson and S O'Hara

23 September 2020

Consolidated Statement of Comprehensive Income

For the six months to 30 June 2020   

Consolidated Statement of Financial Position

As at 30 June 2020