Company Announcements

30 April 2024

Cizzle Biotechnology Holdings Plc

("Cizzle Biotechnology" or the "Company")

Total Voting Rights

Cizzle Biotechnology Holdings PLC (LSE: CIZ), the UK based diagnostics developer, makes the following announcement in accordance with Rule 5.6.1 of the Financial Conduct Authority's ("FCA") Disclosure Guidance and Transparency Rules.

As of 30 April 2024, the Company's issued ordinary share capital consists of 396,391,773 ordinary shares of 0.01 pence each, each with one voting right.  The Company holds no ordinary shares in Treasury.  Therefore, the Company's total number of ordinary shares and voting rights is 396,391,773 and this figure may be used by shareholders as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, the Company under the FCA's Disclosure Guidance and Transparency Rules.

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About Cizzle Biotechnology

Cizzle Biotechnology is developing a blood test to facilitate the early detection of lung cancer based on the ability to detect a stable plasma biomarker, a variant of CIZ1 known as CIZ1B.  CIZ1 is a naturally occurring cell nuclear protein involved in DNA replication, and the targeted CIZ1B variant has been shown to be highly correlated with early-stage lung cancer.  The Company's proprietary technology results from the work of Professor Coverley and colleagues at the University of York.

For more information please see https://cizzlebiotechnology.com

You can also follow the Company through its twitter account @CizzlePlc and on LinkedIn.