Company Announcements

Avacta Group plc

("Avacta" or the "Group" or the "Company")

Payment of Convertible Bond Installment

LONDON and PHILADELPHIA - 21 July 2025 - Avacta (AIM: AVCT), a life sciences company developing innovative, targeted oncology drugs, confirms that further to the announcement of the £3.25m equity financing on 17 July 2025 (the "Placing"), it has settled the quarterly principal of £2.55 million and interest repayment of c.£0.414 million in respect of the Company's unsecured convertible bond in cash. The Placing is due to complete on 24 July 2025.

After settlement of the quarterly repayment, the principal remaining under the convertible bond will be reduced by £2.55 million to £22.95 million.

About Avacta - www.avacta.com

Avacta Therapeutics is a clinical-stage life sciences company expanding the reach of highly potent cancer therapies with the pre|CISION^® platform. pre|CISION^® is a proprietary warhead delivery system based on a tumor-specific protease (fibroblast activation protein or FAP) that is designed to concentrate highly potent warheads in the tumor microenvironment while sparing normal tissues. Our innovative pipeline consists of pre|CISION^® peptide drug conjugates (PDC) or Affimer^® drug conjugates (AffDC) that leverage the tumor-specific release mechanism, providing unique benefits over traditional antibody drug conjugates.

About the pre|CISION^® Platform

The pre|CISION^® platform comprises an anticancer payload conjugated to a proprietary peptide that is a highly specific substrate for fibroblast activation protein (FAP) which is upregulated in most solid tumors compared with healthy tissues. The pre|CISION^® platform harnesses this tumor specific protease to cleave pre|CISION^® peptide drug conjugates and pre|CISION^® antibody/Affimer^® drug conjugates in the tumor microenvironment, thus releasing active payload in the tumor and reducing systemic exposure and toxicity, allowing dosing to be optimized to deliver the best outcomes for patients.