Baxter Presents Critical Care Data at 34th Annual European Society of Intensive Care Medicine LIVES Congress
- Data supports the need for personalized approaches to care for critically ill patients with acute kidney injury (AKI) or sepsis
Baxter-sponsored symposia feature expert perspectives on digital transformation in the intensive care unit and individualized fluid management
“Baxter is dedicated to advancing research that helps clinicians optimize care and improve outcomes for the most critically ill patients, including those with acute kidney injury and sepsis,” said
In one Baxter-sponsored study, investigators found that persistent severe acute kidney injury (PS-AKI) is prevalent among hospitalized adults in
Epidemiology and Clinical Outcomes of Persistent Severe AKI (Abstract #000145)
PS-AKI, a potentially life-threatening condition where kidney injury lasts for three or more days,may be an important determinant of patient outcomes. This study, conducted in collaboration with Premier Applied Sciences® (PAS) and bioMérieux (EPA:BIM), compared characteristics and outcomes for patients with stage 2 or 3 AKI, according to KDIGO (Kidney Disease Improving Global Outcomes) criteria, who developed PS-AKI vs. those who did not (NPS-AKI). This retrospective observational study of 126,528 hospitalized
Baxter and bioMérieux previously announced an agreement to develop and distribute a test to measure the CCL14 biomarker to help improve identification of and personalize treatment for patients at risk of PS-AKI.
Fluid Responsiveness and Creatinine Increase in Patients with Septic Shock (Abstract #000338)
This Baxter-sponsored sub-analysis of the FRESH clinical trial patient population compared patients’ true baseline creatinine levels (prior to hospitalization) to creatinine levels over the course of hospitalization. The findings demonstrated that analyzing patient creatinine levels and fluid responsiveness may help preserve kidney function and decrease the risk of AKI in the septic patient population. Patients with septic shock may be vulnerable to conditions like AKI, and high creatinine levels may indicate that the kidneys are not working properly. Study investigators evaluated 83 patients randomized to the intervention arm who were assessed for fluid responsiveness using Baxter’s Starling Fluid Management Monitoring System before further treatment was administered, and 41 patients randomized to the control arm who received usual care. Patients in the intervention arm received less fluid over a 72-hour period (3354.2 ± 2179.6) compared to the control arm (4721.3 ± 3319.1, p=0.007). Patients in the intervention arm displayed a statistically significant decrease in the need for renal replacement therapy (RRT) to remove fluid and toxins (5.1% vs 17.5%, p= 0.04). Additionally, this sub-analysis showed that 25.9% of patients in the intervention arm exhibited a two-fold increase in creatinine over their true baseline levels, compared to 48% of patients in the control arm (p=0.04).
Additionally, Baxter presented an abstract at ESICM titled “Fluid Responsiveness and Vasopressor Use in Patients with Septic Shock” (Abstract #000340), that further evaluated the administration of vasopressors (drugs used to constrict the blood vessels and raise blood pressure) in the FRESH patient population. The findings suggest that administering fluid only when it is effective at improving perfusion (the passage of fluids through the blood vessels) may lead to improved patient outcomes and does not increase the need for vasopressors and time on treatment.
Starling is currently approved in more than 30 markets globally.
Addressing Key Topics in Critical Care
Baxter sponsored two symposia at ESICM to advance dialogue on important issues:
- “Digital Transformation in the Intensive Care Unit (ICU): What’s Next” featured digital health experts sharing their perspectives on how innovation is fueling quality improvements in data-driven continuous renal replacement therapy (CRRT).
“Fluid Management Wherever You Are” featured a panel of clinical experts discussing best practices for personalized fluid management across different settings, including in the hospital, in the ICU and during the perioperative period.
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This release includes forward-looking statements concerning potential benefits associated with analyzing patient creatinine levels and fluid responsiveness and Baxter’s Starling product. The statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those in the forward-looking statements: demand for and market acceptance for new and existing products; product development risks; inability to create additional production capacity in a timely manner or the occurrence of other manufacturing or supply difficulties (including as a result of natural disasters, public health crises and epidemics/pandemics, regulatory actions or otherwise); satisfaction of regulatory and other requirements; actions of regulatory bodies and other governmental authorities; product quality, manufacturing or supply, or patient safety issues; changes in law and regulations; and other risks identified in Baxter's most recent filing on Form 10-K and other
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