MAIA Biotechnology and Nationwide Children’s Hospital Announce Presentation of THIO’s Potency in Pediatric Brain Tumors at American Association of Cancer Research Annual Meeting
- THIO and ionizing radiation combination shown to significantly decrease cell proliferation and produce potent anticancer effects in highly aggressive, treatment-resistant childhood brain cancer
The research was conducted in collaboration with
DIPG, a very difficult-to-treat and high-risk childhood cancer, is a central nervous system (CNS) tumor that forms in the brainstem. Scientists from Nationwide Children’s Hospital and MAIA have shown that THIO synergistically sensitizes DIPG cells to ionizing radiation (IR), significantly decreasing cell proliferation.
“At the AACR Annual Meeting, we will present study results demonstrating the potential for THIO and IR combinational treatments to stimulate anti-tumor immunity through activation of the
“MAIA is excited to see that the results of our scientific collaborative work with the Nationwide Children’s Hospital were accepted for presentation at the AACR Annual Meeting, a gathering of many of the best minds in cancer research from institutions all over the world,” added Vlad Vitoc, M.D., CEO of MAIA.
MAIA’s presentation at the 2024 AACR Annual Meeting
Abstract #:
5108
Abstract title:
Immunomodulatory and Antitumor Effect of Radiation and Induced Telomere Damage to
Authors:
-
Banlanjo Umaru,
Shiva Senthil Kumar (Center for Childhood Cancer Research ,Nationwide Children's Hospital ,Columbus, OH ) -
Sergei M. Gryaznov (MAIA Biotechnology, Inc. ,Chicago, IL ) -
Rachid Drissi (Center for Childhood Cancer Research ,Nationwide Children's Hospital ,Columbus, OH ;The Ohio State University College of Medicine ,Columbus, OH )
Presenter:
Session date and time:
About THIO
THIO (6-thio-dG or 6-thio-2’-deoxyguanosine) is a first-in-class investigational telomere-targeting agent currently in clinical development to evaluate its activity in Non-Small Cell
About Nationwide Children’s Hospital
Named to the Top 10 Honor Roll on
About
MAIA is a targeted therapy, immuno-oncology company focused on the development and commercialization of potential first-in-class drugs with novel mechanisms of action that are intended to meaningfully improve and extend the lives of people with cancer. Our lead program is THIO, a potential first-in-class cancer telomere targeting agent in clinical development for the treatment of NSCLC patients with telomerase-positive cancer cells. For more information, please visit www.maiabiotech.com.
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