Innovent Announces Mazdutide Demonstrates 80.2% Reduction in Liver Fat Content in Exploratory Analysis of Phase 3 Weight Management GLORY-1 Study at ADA 2024
SAN FRANCISCO and
Mazdutide (Innovent R&D code: IBI362) is a glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) dual agonist. By activating GLP-1R, it reduces appetite and delays gastric emptying, thereby achieving weight loss. At the same time, through activation of GCGR, it increases energy expenditure, enhances fatty acid oxidation and lipolysis, and reduces liver fat.
Professor
In GLORY-1 trial (ClinicalTrial.gov:NCT05607680), 610 Chinese adults with BMI ≥28 kg/m2, or ≥24 kg/m2 and at least one weight-related comorbidity were randomized in a 1:1:1 ratio to receive once-weekly, subcutaneous mazdutide 4 mg, 6 mg or placebo for 48 weeks.
A total of 92 participants had an MRI scan and a liver fat content (LFC) measurement by MRI-PDFF at baseline, among whom 69 participants (25 with mazdutide 4 mg, 22 with mazdutide 6 mg and 22 with placebo) had LFC ≥5% at baseline and week 48 LFC assessment, and were included in this exploratory analysis.
Mazdutide treatment led to robust reduction in LFC and improved liver function
- In 69 participants with baseline LFC ≥5% and week 48 LFC assessment, treatment with mazdutide for 48 weeks dose-dependently reduced LFC, substantially greater than placebo (mean relative change from baseline: −63.3% for mazdutide 4 mg; −73.2% for mazdutide 6 mg; 8.2% for placebo)
- In participants with baseline LFC ≥10%, treatment with mazdutide 6 mg led to mean relative reduction of 80.2% in LFC at week 48.
- Compared with placebo, substantially more participants with mazdutide achieved ≥30% relative reduction in LFC, ≥50% relative reduction in LFC and normalization of LFC (<5%) at week 48. Of note, 95.5% of participants with mazdutide 6 mg achieved ≥30% relative reduction in LFC at week 48, and 77.3% of participants with mazdutide 6mg achieved LFC<5% at week 48.
- Marked reductions in body weight, waist circumference, blood pressure, transaminase and lipids were observed in participants treated with mazdutide.
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About Obesity
As a chronic disease with a complex etiology, obesity is a leading risk factor of type 2 diabetes, fatty liver, cardiovascular and cerebrovascular diseases, kidney diseases, joint diseases, sleep apnea and various cancers. With economic development and lifestyle changes, the number of obese populations in
About Mazdutide (IBI362)
Innovent entered into an exclusive license agreement with Eli Lilly and Company (Lilly) for the development and potential commercialization of OXM3 (also known as mazdutide), a GLP-1R and GCGR dual agonist, in
In
About Innovent
Innovent is a leading biopharmaceutical company founded in 2011 with the mission to empower patients worldwide with affordable, high-quality biopharmaceuticals. The company discovers, develops, manufactures and commercializes innovative medicines that target some of the most intractable diseases. Its pioneering therapies treat cancer, cardiovascular and metabolic, autoimmune and eye diseases. Innovent has launched 10 products in the market. It has 4 new drug applications under regulatory review, 4 assets in Phase III or pivotal clinical trials and 18 more molecules in early clinical stage. Innovent partners with over 30 global healthcare companies, including Eli Lilly, Sanofi, Incyte,
Guided by the motto, "Start with Integrity, Succeed through Action," Innovent maintains the highest standard of industry practices and works collaboratively to advance the biopharmaceutical industry so that first-rate pharmaceutical drugs can become widely accessible. For more information, visit www.innoventbio.com, or follow Innovent on Facebook and LinkedIn.
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References
[i] Pan XF, Wang L, Pan A. Epidemiology and determinants of obesity in |
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