ScaleReady awards a $300,000 G-Rex® Grant to A2 Biotherapeutics, Inc.
"We are very impressed by the simplicity and scalability of the G-Rex platform and look forward to exploring its applications in our clinical development programs." says Dr.
"We appreciate the opportunity to help A2 Biotherapeutics explore an alternative manufacturing pathway that is distinct from the 'all-in-one' bioreactor approach. We believe a modular and flexible closed approach is necessary for cell therapy developers to set the basis for LEAN manufacturing while establishing phase appropriate production. This is the best way to generate drug product supply that is commensurate with their total patient demand," says
As part of the G-Rex Grant, A2 will evaluate the G-CART process, a standardized workflow for assembling CAR-T drug product, currently in development at Cell Ready, the world's first and only G-Rex centric contract development and manufacturing organization (CDMO). The G-CART process is designed for high-throughput manufacturing in centralized or point of care models and will be readily adaptable to full end-to-end robotic automation for commercial scale production. The G-CART process will make creative use of novel sub-assemblies to streamline the flow of the drug substance through the final assembly line, including the new GMP ProPak cytokines from Bio-Techne. ProPaks are GMP grade, liquid formulated, process-sized cytokines filled in sterile-weldable bags tailormade for use with the G-Rex device. Various interleukins, including IL-2, IL-7, and IL-15 are available in
A2's CAR-T cell pipeline is based on their proprietary Tmod™ platform. The Tmod platform is a dual-signal integrator system for cancer cell therapy that consists of an activating receptor and an inhibitory receptor (blocker module). It utilizes tumor loss of heterozygosity to clearly distinguish normal cells containing both the activator and blocker antigens from tumor cells expressing the activator antigen, but which have irreversibly lost the blocker antigen. A2's current clinical pipeline consists of CAR-T cell therapies targeting various solid tumor indications including colorectal, lung, pancreatic, and ovarian cancers.
ScaleReady's G-Rex Grant Program is advancing the state of cell and gene-modified cell therapy (CGT) development and manufacturing by awarding individual Grant Awards worth up to
For more information about the G-Rex® Grant Program, please contact info@scaleready.com .
About ScaleReady
ScaleReady provides the field of cell and gene-modified cell therapy (CGT) with a G-Rex centric manufacturing platform that enables the world's most practical, flexible, scalable, and affordable CGT drug product development and manufacturing.
The G-Rex manufacturing platform is currently used by a rapidly growing list of over 800 organizations and is producing drug products for approximately 50% of CGT clinical trials as well as 5 commercially approved CGT drugs.
CGT entities relying on the breadth and scope of ScaleReady's expertise can expect to save years of time and millions of dollars on the path to CGT commercialization.
For more information about the ScaleReady G-Rex® Grant Program, please contact info@scaleready.com.
About Wilson Wolf Manufacturing
About
Contact:
david.clair@bio-techne.com
612-656-4416
About
CellReady is the world's first and only G-Rex centric contract development and manufacturing organization (CDMO) specializing in G-Rex based cell and gene-modified cell therapy development and manufacturing. The company offers a wide range of services to support the development and commercialization of these therapies.
CellReady's mission is to create hope for cancer patients, one G-Rex® process at a time.
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