Company Announcements

4basebio Plc - Director Dealing

16 February 2026

4basebio PLC

("4basebio" or the "Company")

Director Dealing

Cambridge, UK, 16 February 2026  – 4basebio PLC (AIM: 4BB), an innovation driven biotechnology company enabling and accelerating development of advanced therapy medicinal products (ATMPs) through its high performant GMP-grade synthetic DNA products, announces that on 13 February 2026 it was informed that Dr. Amy Walker, Chief Executive Officer of the Company made the following purchase in ordinary shares in the capital of the Company through the market.

Further details are set out in the Notification of Dealing Form below.


                                                                Shareholding
                                                   Shareholding Following
Director / PCA Number of Ordinary Purchase Price   Following    Acquisition as a
               Shares Acquired    (Aggregated) (p) Acquisition  Percentage of
                                                                Issued Share
                                                                Capital

Dr. Amy Walker 2,650              586.08           46,666       0.30%



The 2,650 shares purchased represent approximately 0.02 per cent. of the Company's issued share capital.

The issued share capital of the Company comprises 15,538,518 ordinary shares.

This announcement contains inside information for the purposes of Article 7 of EU Regulation 596/2014 as amended by regulation 11 of the Market Abuse (Amendment) (EU Exit) Regulations 2019/310.

For further enquiries, please contact:

        4basebio PLC                                     +44 (0)12 2396 7943

Dr Amy Walker, CEO

Cairn Financial Advisers LLP (Nominated Adviser) +44 (0)20 7213 0880

Jo Turner / Sandy Jamieson / Ed Downes

Cavendish Capital Markets Limited (Joint Broker) +44 (0)20 7220 0500

Geoff Nash / Nigel BirksRBC Capital Markets (Joint Broker)               +44 (0)20 7653 4000

Kathryn Deegan / Matthew CoakesICR Healthcare (Media and Investor Relations)    +44 (0)203 707 5700

Mary-Jane Elliott / Jessica Hodgson

Notes to Editors

About 4basebio

4basebio (AIM: 4BB) is an innovation driven life biotechnology company focused on accelerating the development of advanced therapy medicinal products (ATMPs) through its high-performance synthetic DNA products and non-viral, cell targeting nucleic acid delivery platform. The Company’s objective is to become a market leader in the manufacture and supply of high-quality synthetic DNA products for research, therapeutic and pharmacological use as well as development of target specific non-viral vectors for the efficient delivery of payloads in patients.

Forward-looking statements

This announcement may contain certain statements about the future outlook for 4basebio.  Although the directors believe their expectations are based on reasonable assumptions, any statements about future outlook may be influenced by factors that could cause actual outcomes and results to be materially different.

Notification and public disclosure of transactions by persons discharging managerial responsibilities and persons closely associated with them


1  Details of the persons discharging managerial responsibilities / person
   closely associated

a) Name                                         Dr. Amy Walker

2  Reason for the notification

a) Position/Status                              Chief Executive Officer

b) Initial notification/ Amendment              Initial notification

3  Details of the issuer, emission allowance market participant, auction
   platform, auctioneer or auction monitor

a) Name                                         4basebio plc

b) LEI                                          213800E2DX9EAIUNCB30

   Details of the transaction(s): section to be repeated for (i) each type of
4  instrument; (ii) each type of transaction; (iii) each date; and (iv) each
   place where transactions have been conducted

   Description of the financialinstrument, type Ordinary Shares
a) ofinstrumentIdentification code
                                                ISIN: GB00BMCLYF79

b) Nature of the transaction                    Acquisition of ordinary shares


                                                 Price(s) Volume(s)
c) Price(s) and volume(s)
                                                 586.08p  2,650


d) Aggregated information- Aggregated volume-   2,650586.08p
   Aggregated Price

e) Date of transaction                          13 February 2026

f) Place of transaction                         London Stock Exchange