Waters Debuts Industry-First Extended-Range MALS Detector for UHPLC/UPLC, Powering Rapid Characterization of Large Molecules
- Delivers up to 4x faster chromatographic run times to accelerate decisions across discovery, development, and quality workflows.1,3
- Achieves 10x improvement in absolute molar mass and extended sizing, without compromising resolution or analytical throughput.2
- Reduces sample consumption by 30-50% and solvent use by approximately 40%.3
The omniDAWN MALS Photometer extends UPLC-compatible sizing ten-fold, from approximately 50 to 500 nm in radius, enabling reliable characterization of larger, more complex analytes such as protein aggregates, viral vectors, lipid nanoparticles (LNPs), and advanced materials. Because it provides absolute molar mass and size, the omniDAWN Photometer reduces reliance on column calibration standards and supports faster results and more confident comparisons, streamlining work across biosimilarity studies, antibody-drug conjugate (ADC) characterization, and viral vector analytics. As these modalities and other advanced therapeutics move into late-stage development and quality control, laboratories increasingly rely on UHPLC and UPLC Systems to meet rising throughput and resolution requirements.
"Advances in UHPLC and UPLC separations for complex biologics and newer modalities have outpaced detector technology, until now," said
Integrating seamlessly with Waters UPLC Systems and columns, the omniDAWN Photometer eliminates traditional trade-offs between dispersion, robustness, and analytical performance, delivering a complete solution for multi-attribute characterization with improved usability2 compared to micro‑volume MALS approaches. When paired with UHPLC or UPLC Systems, the omniDAWN Photometer supports run times up to four times faster than conventional HPLC workflows, while reducing sample consumption by 30–50% and solvent use by approximately 40%.1,3 Its low dispersion design preserves resolution3 and sensitivity,1,2 while delivering high-quality data across complex samples.1,2 Sharper separations enhance the detection of low-level species, helping scientists distinguish monomer, aggregates, and fragments with greater clarity, supporting informed decision-making across discovery, development, and quality workflows.
"Extending the capabilities of multi-angle light scattering to UHPLC and UPLC analysis will enable absolute molar mass measurements, paired with faster and more flexible separations. This represents a critical leap forward in MALS-based analyses, empowering us to better understand the structure of complex materials across drug delivery and environmental nanotechnology applications, ultimately supporting improved health outcomes," said
The omniDAWN Photometer is powered by ASTRA™ Software, built on more than 40 years of light scattering innovation. By integrating MALS with ultraviolet (UV) and refractive index (RI) detection,
The Waters omniDAWN MALS Photometer will be available globally in summer 2026. To learn more or request a demo, visit www.wyatt.com/omniDAWN.
Additional Resources:
Waters, omniDAWN, UPLC, ASTRA, Empower, and
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References:
- Comparative column and peak width analysis using UHPLC/UPLC versus HPLC SEC formats; internal evaluation. Source: internal data.
- Performance and range of 3-angle MALS compared to 18-angle MALS detector across representative analytes. Source: internal data.
- Performance comparison to conventional HPLC.
Contact:
Head of
Waters Corporation
508.498.9732
molly_gluck@waters.com
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