GeneDx Reports First Quarter 2026 Financial Results and Updates Full-Year Outlook
-
Reported total revenue of
$102.3 million with 27% year-over-year growth in exome and genome revenue - Reported exome and genome volume growth of 34% year-over-year
-
Reported adjusted gross margin(1) of 69% and adjusted net loss(1) of
$8.2 million -
Updating full-year 2026 revenue guidance to
$475 to$490 million with exome and genome volume growth of at least 30% -
Hosting conference call today at
4:30 p.m. ET
“GeneDx delivered 34% year-over-year volume growth in exome and genome testing in the first quarter – a clear signal that there’s sustained, strong demand for our services. While our revenue did not reflect the full potential of what this business is capable of, we are adjusting our outlook and are poised to deliver more than 30% volume growth, 70% gross margin, and profitability on an adjusted basis for the year,” said
First Quarter 2026 Financial Results (Unaudited)(1)
Revenue
-
Revenue grew to
$102.3 million , an increase of 17% year-over-year. -
Exome and genome test revenue grew to
$90.6 million , an increase of 27% year-over-year.
Exome and genome volume
- Exome and genome test result volume grew to 27,488, an increase of 34% year-over-year.
Gross margin
-
Adjusted gross margin remained flat at 69% in the first quarter of 2026.
- GAAP gross margin was 67%.
Operating expenses
-
Adjusted total operating expenses were
$78.1 million , representing 76% of revenue.-
Total GAAP operating expenses were
$94.4 million .
-
Total GAAP operating expenses were
Net (loss) income
-
Adjusted net loss was
$8.2 million compared to adjusted net income of$9.2 million in the first quarter of 2025.-
GAAP net loss was
$63.3 million .
-
GAAP net loss was
Cash position
-
Cash, cash equivalents, marketable securities and restricted cash was
$171.7 million as ofMarch 31, 2026 .
|
(1) |
|
Adjusted gross margin, adjusted total operating expenses and adjusted net (loss) income are non-GAAP financial measures. See appendix for a reconciliation of GAAP to non-GAAP figures presented. |
Updated 2026 Guidance
|
Metric |
|
Full Year 2026 Previous Guidance |
|
Full Year 2026 Updated Guidance |
|
Second Quarter of 2026 Guidance |
|
Revenue |
|
|
|
|
|
|
|
Growth in exome and genome volume |
|
33% to 35% |
|
At least 30% |
|
Approximately 30,000 tests |
|
Growth in exome and genome revenue |
|
33% to 35% |
|
At least 20% |
|
Approximately |
|
Adjusted gross margin |
|
At least 70% |
|
Approximately 70% |
|
Approximately 70% |
|
Adjusted net income (loss) |
|
Positive |
|
Positive |
|
Adj. net loss of approximately |
First Quarter 2026 and Recent Business Highlights
Strategic Expansion and Market Leadership
-
Announced the landmark SAVES-Kids Study, a real-world data
Health Economics and Outcomes Research (HEOR) study showing an average healthcare cost savings of up to$80,000 for children with neurodevelopmental disorders in the 12 months following ExomeDx™ and GenomeDx™ testing, regardless of the test result. - Launched a reflex product, enabling seamless reflexing to genome testing when exome testing is non-diagnostic.
- Partnered with CNBC to launch CNBC Cures, a collaborative, multi-platform initiative aimed at raising awareness for the rare disease community and improving outcomes for the ~30 million Americans affected by rare diseases.
- Launched a sponsored genetic testing program with Zevra Therapeutics to support patients with suspected Niemann-Pick Disease Type C.
-
Expanded Medicaid coverage in
Texas ,Maine , andArkansas , resulting in approximately 4.9 million Medicaid patients gaining access to exome testing.
Innovation & Clinical Leadership
-
Added to the company’s more than 1,100 publications by showcasing 18 pieces of pioneering research at the
American College of Medical Genetics and Genomics (ACMG) Annual Meeting. The research highlighted the scale and clinical impact of GeneDx Infinity™ – the largest and most comprehensive rare disease genomic dataset – and GeneDx’s leadership in bringing exome and genome testing to the standard of care by leveraging AI, world-class data and clinical expertise, and expert variant interpretation and classification. -
Published results from a benchmarking study in the
American Journal of Human Genetics demonstrating HiFi long-read sequencing was successful in identifying difficult to detect variants using real-world clinical samples. -
Published new SeqFirst study data in the
American Journal of Medical Genetics showing that implementing rapid genome sequencing (rWGS) as a first-tier test in pediatric and cardiac intensive care units significantly increases diagnostic rates and reduces time to diagnosis by 50%. -
Presented “Scaling Rare Disease Discovery with AI: From Genomic Data to Therapeutic Insights” at the
Precision Medicine Worldwide Conference (PMWC), showcasing howGeneDx partners with biopharma to turn genomic data into actionable solutions – accelerating discovery, enabling clinical trials, and advancing the next era of precision medicine.
Webcast and Conference Call Details
Non-GAAP Financial Measures
Forward-Looking Statements
This press release contains “forward-looking statements” within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and the
About
GeneDx’s (Nasdaq: WGS) mission is to empower everyone to live their healthiest life through genomics.
Volume & Revenue
|
|
|
1Q26 |
|
|
4Q25 |
|
|
3Q25 |
|
|
2Q25 |
|
|
1Q25 |
|
Volumes |
|
|
|
|
|
|
|
|
|
|||||
|
Whole exome, whole genome |
|
27,488 |
|
|
27,761 |
|
|
25,702 |
|
|
23,246 |
|
|
20,562 |
|
Hereditary cancer |
|
108 |
|
|
346 |
|
|
1,511 |
|
|
2,677 |
|
|
2,725 |
|
Other panels |
|
27,621 |
|
|
30,935 |
|
|
33,003 |
|
|
31,833 |
|
|
28,228 |
|
Total |
|
55,217 |
|
|
59,042 |
|
|
60,216 |
|
|
57,756 |
|
|
51,515 |
|
|
|
|
|
|
|
|
|
|
|
|||||
|
Revenue ($ millions) |
|
|
|
|
|
|
|
|
|
|||||
|
Whole exome, whole genome |
$ |
90.6 |
|
$ |
104.0 |
|
$ |
98.9 |
|
$ |
86.0 |
|
$ |
71.4 |
|
Hereditary cancer |
|
0.1 |
|
|
0.2 |
|
|
1.2 |
|
|
1.8 |
|
|
2.2 |
|
Other panels |
|
10.6 |
|
|
13.1 |
|
|
13.4 |
|
|
12.3 |
|
|
12.1 |
|
Data information |
|
0.8 |
|
|
2.6 |
|
|
1.5 |
|
|
2.0 |
|
|
1.4 |
|
Software and interpretation services |
|
0.2 |
|
|
1.1 |
|
|
1.7 |
|
|
0.6 |
|
|
— |
|
Total |
$ |
102.3 |
|
$ |
121.0 |
|
$ |
116.7 |
|
$ |
102.7 |
|
$ |
87.1 |
Unaudited Select Financial Information (in thousands)
|
|
Three months ended |
|
Three months ended |
||||||||
|
|
|
|
Other(1) |
|
Total |
|
|
|
Other(1) |
|
Total |
|
Revenue |
|
|
|
|
|
|
|
|
$— |
|
|
|
Adjusted cost of services |
31,613 |
|
588 |
|
32,201 |
|
27,396 |
|
— |
|
27,396 |
|
Adjusted gross profit |
|
|
|
|
|
|
|
|
$— |
|
|
|
Adjusted gross margin % |
68.9% |
|
|
|
68.5% |
|
68.6% |
|
|
|
68.6% |
|
(1) |
For the three months ended |
|
|
Three months ended |
|||||||||||||||||||||||||||||
|
|
Reported |
|
Depreciation and amortization |
|
Stock-based compensation |
|
Restructuring costs |
|
Change in FV of financial liabilities |
|
Extinguishment of debt |
|
Other(2) |
|
Adjusted |
|||||||||||||||
|
Diagnostic test revenue |
$ |
101,299 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
— |
|
$ |
— |
|
|
$ |
101,299 |
|
|
Other revenue |
|
955 |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
— |
|
|
|
955 |
|
|
Total revenue |
|
102,254 |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
— |
|
|
|
102,254 |
|
|
Cost of services |
|
34,043 |
|
|
|
(1,462 |
) |
|
|
(380 |
) |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
— |
|
|
|
32,201 |
|
|
Gross profit |
|
68,211 |
|
|
|
1,462 |
|
|
|
380 |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
— |
|
|
|
70,053 |
|
|
Gross margin |
|
66.7 |
% |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
68.5 |
% |
|||||||||||
|
Research and development |
|
19,804 |
|
|
|
(224 |
) |
|
|
(1,406 |
) |
|
|
(224 |
) |
|
|
— |
|
|
|
— |
|
|
— |
|
|
|
17,950 |
|
|
Selling, general and administrative |
|
74,591 |
|
|
|
(5,123 |
) |
|
|
(7,210 |
) |
|
|
(215 |
) |
|
|
— |
|
|
|
— |
|
|
(1,916 |
) |
|
|
60,127 |
|
|
Impairment loss |
|
31,287 |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
(31,287 |
) |
|
|
— |
|
|
Loss from operations |
|
(57,471 |
) |
|
|
6,809 |
|
|
|
8,996 |
|
|
|
439 |
|
|
|
— |
|
|
|
— |
|
|
33,203 |
|
|
|
(8,024 |
) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||||||||||||
|
Interest expense, net |
|
(717 |
) |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
717 |
|
|
|
— |
|
|
Other (expense) income, net |
|
(4,231 |
) |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(2,540 |
) |
|
|
6,565 |
|
|
— |
|
|
|
(206 |
) |
|
Income tax expense |
|
(897 |
) |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
897 |
|
|
|
— |
|
|
Net loss |
$ |
(63,316 |
) |
|
$ |
6,809 |
|
|
$ |
8,996 |
|
|
$ |
439 |
|
|
$ |
(2,540 |
) |
|
$ |
6,565 |
|
$ |
34,817 |
|
|
$ |
(8,230 |
) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||||||||||||
|
Basic and diluted loss per share(1) |
$ |
(2.16 |
) |
|
|
|
|
|
|
|
|
|
|
|
|
|
$ |
(0.28 |
) |
|||||||||||
|
|
Three months ended |
|||||||||||||||||||||||||||||
|
|
Reported |
|
Depreciation and amortization |
|
Stock-based compensation |
|
Restructuring costs |
|
Change in FV of financial liabilities |
|
Other(2) |
|
Adjusted |
|||||||||||||||||
|
Diagnostic test revenue |
$ |
85,759 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
— |
|
|
|
$ |
85,759 |
|
||||||
|
Other revenue |
|
1,356 |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
— |
|
|
|
1,356 |
|
||||
|
Total revenue |
|
87,115 |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
— |
|
|
|
87,115 |
|
||||
|
Cost of services |
|
28,639 |
|
|
|
(1,075 |
) |
|
|
(168 |
) |
|
|
— |
|
|
|
— |
|
|
— |
|
|
|
27,396 |
|
||||
|
Gross profit |
|
58,476 |
|
|
|
1,075 |
|
|
|
168 |
|
|
|
— |
|
|
|
— |
|
|
— |
|
|
|
59,719 |
|
||||
|
Gross margin |
|
67.1 |
% |
|
|
|
|
|
|
|
|
|
|
|
|
68.6 |
% |
|||||||||||||
|
Research and development |
|
12,577 |
|
|
|
(372 |
) |
|
|
(419 |
) |
|
|
(28 |
) |
|
|
— |
|
|
— |
|
|
|
11,758 |
|
||||
|
Selling, general and administrative |
|
50,450 |
|
|
|
(4,231 |
) |
|
|
(3,396 |
) |
|
|
(530 |
) |
|
|
— |
|
|
(3,265 |
) |
|
|
39,028 |
|
||||
|
(Loss) income from operations |
|
(4,551 |
) |
|
|
5,678 |
|
|
|
3,983 |
|
|
|
558 |
|
|
|
— |
|
|
3,265 |
|
|
|
8,933 |
|
||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||||||||||||||
|
Interest expense, net |
|
(640 |
) |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
640 |
|
|
|
— |
|
||||
|
Other (expense) income, net |
|
(891 |
) |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
1,100 |
|
|
30 |
|
|
|
239 |
|
||||
|
Income tax expense |
|
(447 |
) |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
447 |
|
|
|
— |
|
||||
|
Net (loss) income |
$ |
(6,529 |
) |
|
$ |
5,678 |
|
|
$ |
3,983 |
|
|
$ |
558 |
|
|
$ |
1,100 |
|
$ |
4,382 |
|
|
$ |
9,172 |
|
||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||||||||||||||
|
Basic (loss) earnings per share(1) |
$ |
(0.23 |
) |
|
|
|
|
|
|
|
|
|
|
|
$ |
0.33 |
|
|||||||||||||
|
Diluted (loss) earnings per share(1) |
$ |
(0.23 |
) |
|
|
|
|
|
|
|
|
|
|
|
$ |
0.31 |
|
|||||||||||||
|
(1) |
|
Basic and diluted (loss) earnings per share are calculated based on 29,335,126 weighted average shares outstanding for the three months ended |
|
(2) |
|
Other represents interest expense, net, income tax expense and non-core lease costs for all periods presented. For the three months ended |
|
Condensed Consolidated Balance Sheets (in thousands, except share and per share amounts) |
|||||||
|
|
|
|
|
||||
|
Assets: |
|
|
|
||||
|
Current assets: |
|
|
|
||||
|
Cash and cash equivalents |
$ |
93,924 |
|
|
$ |
104,997 |
|
|
Marketable securities |
|
76,761 |
|
|
|
66,285 |
|
|
Accounts receivable |
|
76,929 |
|
|
|
74,370 |
|
|
Inventory, net |
|
12,241 |
|
|
|
13,951 |
|
|
Prepaid expenses and other current assets |
|
10,774 |
|
|
|
8,685 |
|
|
Total current assets |
|
270,629 |
|
|
|
268,288 |
|
|
Operating lease right-of-use assets |
|
34,653 |
|
|
|
23,412 |
|
|
Property and equipment, net |
|
50,125 |
|
|
|
45,693 |
|
|
|
|
1,641 |
|
|
|
13,520 |
|
|
Intangible assets, net |
|
144,969 |
|
|
|
168,481 |
|
|
Other assets(1) |
|
4,284 |
|
|
|
4,316 |
|
|
Total assets |
$ |
506,301 |
|
|
$ |
523,710 |
|
|
Liabilities and Stockholders’ Equity: |
|
|
|
||||
|
Current liabilities: |
|
|
|
||||
|
Accounts payable and accrued expenses |
$ |
46,562 |
|
|
$ |
57,645 |
|
|
Short-term lease liabilities |
|
5,129 |
|
|
|
4,404 |
|
|
Other current liabilities |
|
35,948 |
|
|
|
46,859 |
|
|
Total current liabilities |
|
87,639 |
|
|
|
108,908 |
|
|
Long-term debt, net of current portion |
|
96,732 |
|
|
|
48,176 |
|
|
Long-term lease liabilities |
|
66,331 |
|
|
|
56,046 |
|
|
Other liabilities |
|
71 |
|
|
|
1,641 |
|
|
Deferred taxes |
|
1,404 |
|
|
|
757 |
|
|
Total liabilities |
|
252,177 |
|
|
|
215,528 |
|
|
Stockholders’ Equity: |
|
|
|
||||
|
Preferred stock |
|
— |
|
|
|
— |
|
|
Class A common stock |
|
3 |
|
|
|
3 |
|
|
Additional paid-in capital |
|
1,690,249 |
|
|
|
1,680,738 |
|
|
Accumulated deficit |
|
(1,436,811 |
) |
|
|
(1,373,495 |
) |
|
Accumulated other comprehensive income |
|
683 |
|
|
|
936 |
|
|
Total stockholders’ equity |
|
254,124 |
|
|
|
308,182 |
|
|
Total liabilities and stockholders’ equity |
$ |
506,301 |
|
|
$ |
523,710 |
|
|
(1) |
Other assets includes |
|
Condensed Consolidated Statements of Operations (Unaudited) (in thousands, except share and per share amounts) |
|||||||
|
|
Three months ended |
||||||
|
|
|
2026 |
|
|
|
2025 |
|
|
Revenue |
|
|
|
||||
|
Diagnostic test revenue |
$ |
101,299 |
|
|
$ |
85,759 |
|
|
Other revenue |
|
955 |
|
|
|
1,356 |
|
|
Total revenue |
|
102,254 |
|
|
|
87,115 |
|
|
Cost of services |
|
34,043 |
|
|
|
28,639 |
|
|
Gross profit |
|
68,211 |
|
|
|
58,476 |
|
|
Research and development |
|
19,804 |
|
|
|
12,577 |
|
|
Selling, general and administrative |
|
74,591 |
|
|
|
50,450 |
|
|
Impairment loss |
|
31,287 |
|
|
|
— |
|
|
Loss from operations |
|
(57,471 |
) |
|
|
(4,551 |
) |
|
|
|
|
|
||||
|
Non-operating (expenses) income, net |
|
|
|
||||
|
Change in fair value of financial liabilities |
|
2,540 |
|
|
|
(1,100 |
) |
|
Interest expense, net |
|
(717 |
) |
|
|
(640 |
) |
|
Loss on extinguishment of debt |
|
(6,565 |
) |
|
|
— |
|
|
Other (expense) income, net |
|
(206 |
) |
|
|
209 |
|
|
Total non-operating expense, net |
|
(4,948 |
) |
|
|
(1,531 |
) |
|
Loss before income taxes |
|
(62,419 |
) |
|
|
(6,082 |
) |
|
Income tax expense |
|
(897 |
) |
|
|
(447 |
) |
|
Net loss |
$ |
(63,316 |
) |
|
$ |
(6,529 |
) |
|
|
|
|
|
||||
|
Weighted-average shares outstanding of Class A common stock |
|
29,335,126 |
|
|
|
28,147,948 |
|
|
Basic and diluted loss per share, Class A common stock |
$ |
(2.16 |
) |
|
$ |
(0.23 |
) |
|
Condensed Consolidated Statements of Cash Flows (Unaudited) (in thousands) |
|||||||
|
|
Three months ended |
||||||
|
|
|
2026 |
|
|
|
2025 |
|
|
Operating activities |
|
|
|
||||
|
Net loss |
$ |
(63,316 |
) |
|
$ |
(6,529 |
) |
|
Adjustments to reconcile net loss to net cash (used in) provided by operating activities: |
|
|
|
||||
|
Depreciation and amortization expense |
|
6,809 |
|
|
|
5,678 |
|
|
Stock-based compensation expense |
|
8,996 |
|
|
|
3,983 |
|
|
Change in fair value of financial liabilities |
|
(2,540 |
) |
|
|
1,100 |
|
|
Deferred tax expense |
|
897 |
|
|
|
447 |
|
|
Change in third party payor reserves |
|
1,022 |
|
|
|
1,395 |
|
|
Loss on extinguishment of debt |
|
6,565 |
|
|
|
— |
|
|
Impairment loss |
|
31,287 |
|
|
|
— |
|
|
Other |
|
1,034 |
|
|
|
757 |
|
|
Change in operating assets and liabilities: |
|
|
|
||||
|
Accounts receivable |
|
(2,558 |
) |
|
|
(8,557 |
) |
|
Inventory |
|
1,689 |
|
|
|
(2,032 |
) |
|
Accounts payable and accrued expenses |
|
(13,168 |
) |
|
|
10,824 |
|
|
Other assets and liabilities |
|
(9,125 |
) |
|
|
3,116 |
|
|
Net cash (used in) provided by operating activities |
|
(32,408 |
) |
|
|
10,182 |
|
|
Investing activities |
|
|
|
||||
|
Purchases of marketable securities |
|
(20,177 |
) |
|
|
(17,209 |
) |
|
Proceeds from sales of marketable securities |
|
875 |
|
|
|
— |
|
|
Proceeds from maturities of marketable securities |
|
8,500 |
|
|
|
13,930 |
|
|
Purchases of property and equipment and development of internal-use software |
|
(6,453 |
) |
|
|
(6,129 |
) |
|
Net cash used in investing activities |
|
(17,255 |
) |
|
|
(9,408 |
) |
|
Financing activities |
|
|
|
||||
|
Proceeds from long term debt, net of issuance costs |
|
96,998 |
|
|
|
13,894 |
|
|
Proceeds from issuance of common stock from subscription agreements |
|
476 |
|
|
|
— |
|
|
Exercise of stock options |
|
58 |
|
|
|
735 |
|
|
Repayment of long-term debt, including prepayment penalty - Perceptive |
|
(54,000 |
) |
|
|
— |
|
|
Repayment and principal payments for long-term debt - DECD |
|
(4,447 |
) |
|
|
(300 |
) |
|
Finance lease principal payments |
|
(495 |
) |
|
|
(611 |
) |
|
Net cash provided by financing activities |
|
38,590 |
|
|
|
13,718 |
|
|
Net (decrease) increase in cash, cash equivalents and restricted cash |
|
(11,073 |
) |
|
|
14,492 |
|
|
Cash, cash equivalents and restricted cash, at beginning of period |
|
105,989 |
|
|
|
86,202 |
|
|
Cash, cash equivalents and restricted cash, at end of period (1) |
$ |
94,916 |
|
|
$ |
100,694 |
|
|
|
|
|
|
||||
|
Supplemental disclosures of cash flow information |
|
|
|
||||
|
Cash paid for interest |
$ |
1,748 |
|
|
$ |
1,600 |
|
|
Cash paid for taxes |
$ |
754 |
|
|
$ |
206 |
|
|
Lease liability from obtaining right-of-use asset |
$ |
12,086 |
|
|
$ |
— |
|
|
Purchases of property and equipment in accounts payable and accrued expenses |
$ |
5,915 |
|
|
$ |
2,197 |
|
|
(1) |
Cash, cash equivalents and restricted cash as of |
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