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About the company
Spruce Biosciences, Inc. is a late-stage biopharmaceutical company focused on developing and commercializing therapies for neurological disorders with significant unmet medical need. The Company has acquired an exclusive worldwide license agreement for tralesinidase alfa enzyme replacement therapy (TA-ERT) for the treatment of Sanfilippo Syndrome Type B (MPS IIIB). The TA-ERT is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase (rhNAGLU) with modified human insulin-like growth factor 2 via an amino acid linker. TA-ERT is intended as an enzyme replacement therapy for the treatment of patients with MPS IIIB who lack rhNAGLU enzyme activity. The Company's pipeline also includes Tildacerfont and Cortibon for the treatment of Major Depressive Disorder, SPR202 for the treatment of Congenital Adrenal Hyperplasia and SPR204 for the treatment of Post-Bariatric Hypoglycemia.
- Revenue in USD (TTM)697.00k
- Net income in USD-47.88m
- Incorporated2014
- Employees9.00
- LocationSpruce Biosciences Inc611 Gateway Boulevard, Suite 740SOUTH SAN FRANCISCO 94080United StatesUSA
- Phone+1 (415) 655-4168
- Fax+1 (302) 636-5454
- Websitehttps://sprucebio.com/
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Peer analysis
Key Information
- Key Information
- Stock Performance
- Per Share Data
- Efficiency
- Management Effectiveness
- Profitability
- Financial Strength
- Growth Rates
| Company | Revenue (TTM) | Net income (TTM) | Market cap | Employees | Price/earnings (TTM) | Price/book value (MRQ) | Price/cash flow (TTM) | Price/sales (TTM) | EPS (excl. extraordinary items, TTM) | EPS (incl. extraordinary items, TTM) | Revenue per share (TTM) | Book value per share (MRQ) | Asset turnover (TTM) | Inventory turnover (TTM) | Receivables turnover (TTM) | Revenues per employee (TTM) | Return on avg assets (TTM) | Return on avg assets (5 yr avg) | Return on investment (TTM) | Return on investment (5 yr avg) | Gross margin (TTM) | Gross margin (5 yr avg) | Net profit margin (TTM) | Net Profit margin (5 yr avg) | Quick ratio (MRQ) | Interest coverage (TTM) | Total debt to capital (MRQ) | Payout ratio (5 yr avg) | Revenue (YOY change %) | Revenue (5 yr growth rate) | Net income (YOY change %) | Net income (5 yr growth rate) | Capital expenditure (5 yr growth rate) | Dividend (5 yr growth rate) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Annovis Bio Inc | 0.00 | -24.88m | 62.81m | 8.00 | -- | 3.64 | -- | -- | -1.41 | -1.41 | 0.00 | 0.6517 | 0.00 | -- | -- | 0.00 | -157.74 | -116.87 | -221.93 | -138.75 | -- | -- | -- | -- | -- | -- | 0.00 | -- | -- | -- | 56.25 | -- | -- | -- |
| Fractyl Health Inc | 3.00k | -122.20m | 64.17m | 107.00 | -- | -- | -- | 21,390.29 | -2.27 | -2.27 | 0.00006 | -0.024 | 0.00002 | -- | -- | 28.04 | -101.33 | -78.52 | -118.18 | -97.44 | 100.00 | -- | -4,073,233.00 | -122,747.90 | -- | -31.40 | 1.12 | -- | -22.50 | -- | 25.29 | -- | 78.65 | -- |
| Adicet Bio Inc | 0.00 | -115.01m | 66.19m | 152.00 | -- | 0.3294 | -- | -- | -20.22 | -20.22 | 0.00 | 20.98 | 0.00 | -- | -- | 0.00 | -59.52 | -36.24 | -66.08 | -39.41 | -- | -- | -- | -813.80 | -- | -- | 0.0088 | -- | -- | -- | 17.90 | -- | 32.77 | -- |
| Gain Therapeutics Inc | 0.00 | -19.39m | 69.62m | 23.00 | -- | 11.02 | -- | -- | -0.6364 | -0.6364 | 0.00 | 0.1643 | 0.00 | -- | -- | 0.00 | -153.07 | -79.58 | -234.03 | -95.32 | -- | -- | -- | -19,975.78 | -- | -33.79 | 0.067 | -- | -100.00 | -- | 8.34 | -- | 10.39 | -- |
| Coeptis Therapeutics Holdings Inc | 500.99k | -11.28m | 69.78m | 5.00 | -- | 6.03 | -- | 139.29 | -3.47 | -3.47 | 0.1476 | 2.01 | 0.0433 | -- | 11.65 | 100,198.00 | -118.13 | -42.24 | -167.86 | -44.32 | 72.96 | -- | -2,727.81 | -- | -- | -73.66 | 0.0224 | -- | -- | -- | 53.85 | -- | -- | -- |
| Spruce Biosciences Inc | 697.00k | -47.88m | 70.95m | 9.00 | -- | 6.94 | -- | 101.80 | -84.64 | -84.64 | 1.22 | 9.56 | 0.0173 | -- | -- | 33,190.48 | -119.08 | -43.45 | -161.94 | -49.92 | -- | -- | -6,869.30 | -1,459.77 | -- | -353.48 | 0.091 | -- | -51.32 | -- | -10.68 | -- | -- | -- |
| Maia Biotechnology Inc | 0.00 | -22.34m | 71.10m | 13.00 | -- | 1,587.38 | -- | -- | -0.7504 | -0.7504 | 0.00 | 0.0012 | 0.00 | -- | -- | 0.00 | -212.50 | -208.29 | -602.02 | -373.18 | -- | -- | -- | -- | -- | -- | 0.00 | -- | -- | -- | -17.61 | -- | -- | -- |
| Medicinova Inc | 257.92k | -12.01m | 72.74m | 13.00 | -- | 1.65 | -- | 282.01 | -0.2449 | -0.2449 | 0.0053 | 0.8964 | 0.0049 | -- | -- | 19,840.00 | -22.73 | -15.56 | -24.08 | -16.17 | -- | -- | -4,656.61 | -1,144.98 | -- | -- | 0.00 | -- | -100.00 | -- | -28.91 | -- | -39.68 | -- |
| XBiotech Inc | 0.00 | -29.16m | 74.69m | 88.00 | -- | 0.4471 | -- | -- | -0.9566 | -0.9566 | 0.00 | 5.48 | 0.00 | -- | -- | 0.00 | -15.25 | -7.74 | -16.08 | -8.02 | -- | -- | -- | -187.68 | -- | -- | 0.00 | -- | -- | -- | -56.90 | -- | 44.92 | -- |
| Seres Therapeutics Inc | 351.00k | 5.39m | 76.62m | 103.00 | 14.38 | 1.70 | 7.93 | 218.30 | 0.5892 | 0.5892 | 0.0404 | 4.99 | 0.0022 | -- | -- | 3,407.77 | 3.35 | -42.44 | 4.59 | -55.22 | -- | -- | 1,536.75 | -367.23 | -- | -- | 0.00 | -- | -- | -- | 33.85 | -- | -17.63 | -- |
| Ibio Inc | 500.00k | -20.11m | 76.69m | 20.00 | -- | 0.8024 | -- | 153.37 | -1.44 | -1.44 | 0.0232 | 2.77 | 0.0113 | -- | 15.38 | 25,000.00 | -45.35 | -30.90 | -50.81 | -37.76 | -- | -- | -4,021.60 | -2,374.12 | -- | -- | 0.0127 | -- | 77.78 | -24.57 | -19.00 | -- | -57.50 | -- |
| Nuo Therapeutics Inc | 2.61m | -2.43m | 77.25m | -- | -- | -- | -- | 29.58 | -0.0517 | -0.0517 | 0.0555 | -0.0088 | 1.43 | 4.19 | 5.32 | -- | -133.29 | -121.45 | -289.99 | -243.05 | 70.38 | 78.52 | -93.06 | -424.19 | 1.00 | -17,110.33 | -- | -- | 124.34 | 56.34 | 26.73 | -- | -- | -- |
| ImageneBio Inc | 0.00 | -46.14m | 77.27m | 15.00 | -- | 0.5526 | -- | -- | -8.11 | -8.11 | 0.00 | 12.51 | 0.00 | -- | -- | 0.00 | -29.23 | -29.58 | -31.29 | -33.67 | -- | -- | -- | -407.25 | -- | -- | 0.00 | -- | -100.00 | -- | 27.77 | -- | -- | -- |
| Tenax Therapeutics Inc | 0.00 | -43.33m | 78.98m | 4.00 | -- | 0.7767 | -- | -- | -1.13 | -1.13 | 0.00 | 16.29 | 0.00 | -- | -- | 0.00 | -42.77 | -99.65 | -44.80 | -118.65 | -- | -- | -- | -- | -- | -- | 0.00 | -- | -- | -- | -128.28 | -- | -- | -- |
Data as of Feb 17 2026. Currency figures normalised to Spruce Biosciences Inc's reporting currency: US Dollar USD
47.69%Per cent of shares held by top holders
| Holder | Shares | % Held |
|---|---|---|
| Ikarian Capital LLCas of 31 Oct 2025 | 121.36k | 11.34% |
| Citadel Advisors LLCas of 09 Oct 2025 | 109.65k | 10.24% |
| Squadron Capital Management LLCas of 08 Oct 2025 | 70.00k | 6.54% |
| Wellington Management Co. LLPas of 31 Dec 2025 | 58.95k | 5.51% |
| Alyeska Investment Group LPas of 31 Dec 2025 | 51.67k | 4.83% |
| Cable Car Capital LPas of 30 Sep 2025 | 26.67k | 2.49% |
| Quinn Opportunity Partners LLCas of 31 Dec 2025 | 22.81k | 2.13% |
| Stonepine Capital Management LLCas of 31 Dec 2025 | 19.74k | 1.84% |
| BlackRock Fund Advisorsas of 31 Dec 2025 | 16.94k | 1.58% |
| Geode Capital Management LLCas of 31 Dec 2025 | 12.73k | 1.19% |
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Data from 30 Sep 2025 - 31 Dec 2025Source: FactSet Research Systems Inc.
