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About the company
Denali Therapeutics Inc. is a biopharmaceutical company. The Company is focused on developing a portfolio of product candidates engineered to cross the blood-brain barrier (BBB) for neurodegenerative diseases and lysosomal storage disease. The Company has a portfolio of both small molecule and biotherapeutic medicines, comprising seven product candidates in clinical development across seven indications as well as preclinical therapeutic candidates. Its three late-stage development programs include tividenofusp alfa (DNL310) for mucopolysaccharidosis II (MPS II); BIIB122/DNL151 (LRRK2 inhibitor) for Parkinson’s disease; and DNL343 (eIF2B activator) for amyotrophic lateral sclerosis (ALS). SAR443820/DNL788 (RIPK1 inhibitor) is being evaluated in a Phase II study for multiple sclerosis (MS). In addition, it has a Phase I/II study of TAK-594/DNL593 for frontotemporal dementia-granulin (FTD-GRN) and a Phase I/II study of DNL126 for MPS IIIA (Sanfilippo syndrome).
- Revenue in USD (TTM)330.53m
- Net income in USD-145.22m
- Incorporated2013
- Employees445.00
- LocationDenali Therapeutics Inc161 Oyster Point BlvdSOUTH SAN FRANCISCO 94080-1910United StatesUSA
- Phone+1 (650) 866-8548
- Fax+1 (302) 655-5049
- Websitehttps://www.denalitherapeutics.com
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Peer analysis
Key Information
- Key Information
- Stock Performance
- Per Share Data
- Efficiency
- Management Effectiveness
- Profitability
- Financial Strength
- Growth Rates
| Company | Revenue (TTM) | Net income (TTM) | Market cap | Employees | Price/earnings (TTM) | Price/book value (MRQ) | Price/cash flow (TTM) | Price/sales (TTM) | EPS (excl. extraordinary items, TTM) | EPS (incl. extraordinary items, TTM) | Revenue per share (TTM) | Book value per share (MRQ) | Asset turnover (TTM) | Inventory turnover (TTM) | Receivables turnover (TTM) | Revenues per employee (TTM) | Return on avg assets (TTM) | Return on avg assets (5 yr avg) | Return on investment (TTM) | Return on investment (5 yr avg) | Gross margin (TTM) | Gross margin (5 yr avg) | Net profit margin (TTM) | Net Profit margin (5 yr avg) | Quick ratio (MRQ) | Interest coverage (TTM) | Total debt to capital (MRQ) | Payout ratio (5 yr avg) | Revenue (YOY change %) | Revenue (5 yr growth rate) | Net income (YOY change %) | Net income (5 yr growth rate) | Capital expenditure (5 yr growth rate) | Dividend (5 yr growth rate) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Arvinas Inc | 78.50m | -367.30m | 2.22bn | 445.00 | -- | 3.34 | -- | 28.22 | -6.62 | -6.62 | 1.45 | 9.71 | 0.061 | -- | 157.00 | 176,404.50 | -28.35 | -22.01 | -36.10 | -26.47 | -- | -- | -464.71 | -316.55 | -- | -- | 0.0012 | -- | -40.26 | 40.53 | -30.02 | -- | 0.4852 | -- |
| Maravai Lifesciences Holdings Inc | 288.95m | -119.03m | 2.22bn | 650.00 | -- | 5.31 | -- | 7.67 | -0.901 | -0.901 | 2.19 | 1.66 | 0.1533 | 3.15 | 2.99 | 444,530.80 | -7.34 | 12.67 | -9.75 | 15.46 | 48.52 | 74.79 | -47.89 | 37.32 | 7.41 | -0.3566 | 0.4134 | 0.00 | -67.28 | 18.47 | -154.05 | -- | 78.56 | -- |
| Kymera Therapeutics Inc | 78.59m | -146.96m | 2.23bn | 187.00 | -- | 5.11 | -- | 28.34 | -2.52 | -2.52 | 1.35 | 7.11 | 0.1333 | -- | 7.38 | 420,278.10 | -24.93 | -23.03 | -28.76 | -27.64 | -- | -- | -186.99 | -207.82 | -- | -- | 0.0065 | -- | 67.84 | -- | 5.07 | -- | 91.01 | -- |
| Intellia Therapeutics Inc | 36.28m | -481.19m | 2.24bn | 526.00 | -- | 2.06 | -- | 61.65 | -5.42 | -5.42 | 0.4106 | 11.29 | 0.0257 | -- | 1.80 | 68,963.88 | -34.11 | -31.34 | -37.31 | -34.53 | -- | -- | -1,326.51 | -654.71 | -- | -- | 0.00 | -- | -30.40 | 3.57 | -1.48 | -- | 17.08 | -- |
| Dyne Therapeutics Inc | 0.00 | -235.94m | 2.24bn | 141.00 | -- | 17.51 | -- | -- | -3.94 | -3.94 | 0.00 | 1.49 | 0.00 | -- | -- | 0.00 | -100.10 | -52.81 | -120.31 | -57.45 | -- | -- | -- | -- | -- | -- | 0.00 | -- | -- | -- | -40.36 | -- | 40.32 | -- |
| Guardant Health Inc | 563.95m | -479.45m | 2.26bn | 1.78k | -- | 14.24 | -- | 4.02 | -4.28 | -4.28 | 5.04 | 1.30 | 0.3321 | 4.00 | 6.06 | 317,002.80 | -28.23 | -22.26 | -31.99 | -24.59 | 59.74 | 64.62 | -85.02 | -97.07 | 6.24 | -12.04 | 0.8778 | -- | 25.45 | 44.14 | 26.76 | -- | 0.2786 | -- |
| Vericel Corp | 197.52m | -3.18m | 2.32bn | 314.00 | -- | 10.14 | 1,478.28 | 11.73 | -0.0684 | -0.0684 | 4.15 | 4.72 | 0.6304 | 4.26 | 3.77 | 629,031.90 | -1.02 | -3.07 | -1.17 | -3.50 | 68.64 | 67.87 | -1.61 | -4.49 | 4.21 | -- | 0.0004 | -- | 20.17 | 16.80 | 80.96 | -- | 59.35 | -- |
| Geron Corp | 237.00k | -184.13m | 2.32bn | 141.00 | -- | 8.68 | -- | 9,781.87 | -0.3246 | -0.3246 | 0.0004 | 0.455 | 0.0008 | -- | 0.0988 | 1,680.85 | -62.99 | -51.32 | -92.09 | -64.90 | -- | -- | -77,690.72 | -19,949.13 | -- | -- | 0.2484 | -- | -60.23 | -25.97 | -29.76 | -- | 120.29 | -- |
| Vera Therapeutics Inc | 0.00 | -95.99m | 2.37bn | 51.00 | -- | 19.02 | -- | -- | -2.28 | -2.28 | 0.00 | 2.29 | 0.00 | -- | -- | 0.00 | -62.54 | -- | -74.10 | -- | -- | -- | -- | -- | -- | -- | 0.3291 | -- | -- | -- | -7.79 | -- | -- | -- |
| Denali Therapeutics Inc | 330.53m | -145.22m | 2.40bn | 445.00 | -- | 2.26 | -- | 7.25 | -1.09 | -1.09 | 2.39 | 7.45 | 0.2529 | -- | -- | 742,766.30 | -11.11 | -14.98 | -13.37 | -17.71 | -- | -- | -43.94 | -104.50 | -- | -- | 0.00 | -- | 204.74 | 20.67 | 55.45 | -- | 30.70 | -- |
| Avidity Biosciences Inc | 9.56m | -212.22m | 2.43bn | 253.00 | -- | 4.05 | -- | 254.05 | -2.90 | -2.90 | 0.131 | 6.32 | 0.0151 | -- | -- | 37,786.56 | -33.49 | -31.61 | -37.40 | -34.45 | -- | -- | -2,219.88 | -1,540.50 | -- | -- | 0.00 | -- | 3.64 | 90.71 | -21.97 | -- | 143.89 | -- |
| Rhythm Pharmaceuticals Inc | 77.43m | -184.68m | 2.50bn | 226.00 | -- | 14.35 | -- | 32.27 | -3.19 | -3.19 | 1.34 | 2.86 | 0.2165 | 1.61 | 7.34 | 342,601.80 | -51.64 | -47.21 | -59.55 | -52.84 | 87.99 | -- | -238.52 | -681.38 | 5.43 | -- | 0.3847 | -- | 227.56 | -- | -1.97 | -- | -42.10 | -- |
| TG Therapeutics Inc | 289.33m | 41.20m | 2.54bn | 264.00 | 74.47 | -- | 48.72 | 8.76 | 0.2205 | 0.2205 | 1.97 | -- | -- | -- | -- | 1,095,962.00 | -- | -62.87 | -- | -80.06 | 93.53 | -- | 14.24 | -405.03 | -- | 4.01 | -- | -- | 8,290.02 | 333.86 | 106.39 | -- | -- | -- |
| PTC Therapeutics, Inc. | 927.56m | -579.22m | 2.58bn | 988.00 | -- | -- | -- | 2.78 | -7.69 | -7.69 | 12.28 | -11.66 | 0.5459 | 2.33 | 4.64 | 938,823.90 | -34.09 | -26.71 | -48.63 | -33.46 | 92.88 | 93.94 | -62.45 | -83.80 | 1.98 | -0.7975 | 1.72 | -- | 34.20 | 28.78 | -12.09 | -- | 32.00 | -- |
| Corcept Therapeutics Incorporated | 482.38m | 106.14m | 2.60bn | 352.00 | 26.26 | 5.11 | 24.28 | 5.39 | 0.9542 | 0.9542 | 4.32 | 4.90 | 0.8007 | 0.9374 | 13.37 | 1,370,384.00 | 17.62 | 21.17 | 20.65 | 23.85 | 98.66 | 98.52 | 22.00 | 27.23 | 4.31 | -- | 0.00 | 0.00 | 20.04 | 13.93 | 4.66 | 7.08 | -14.15 | -- |
| Hims & Hers Health Inc | 872.00m | -23.55m | 2.62bn | 1.05k | -- | 7.60 | -- | 3.01 | -0.1131 | -0.1131 | 4.17 | 1.61 | 2.16 | 7.13 | 195.17 | 833,652.00 | -5.83 | -- | -7.02 | -- | 81.99 | -- | -2.70 | -- | 2.74 | -- | 0.00 | -- | 65.49 | -- | 64.15 | -- | -- | -- |
Data as of May 02 2024. Currency figures normalised to Denali Therapeutics Inc's reporting currency: US Dollar USD
48.66%Per cent of shares held by top holders
| Holder | Shares | % Held |
|---|---|---|
| Baillie Gifford & Co.as of 31 Dec 2023 | 14.26m | 10.25% |
| The Vanguard Group, Inc.as of 31 Dec 2023 | 10.50m | 7.54% |
| BlackRock Fund Advisorsas of 31 Dec 2023 | 9.47m | 6.80% |
| Wellington Management Co. LLPas of 31 Dec 2023 | 7.27m | 5.23% |
| Temasek Holdings Pte Ltd. (Investment Management)as of 31 Dec 2023 | 6.90m | 4.96% |
| Crestline Management LPas of 31 Dec 2023 | 5.66m | 4.07% |
| SSgA Funds Management, Inc.as of 31 Dec 2023 | 5.49m | 3.94% |
| Capital Research & Management Co. (Global Investors)as of 31 Dec 2023 | 2.91m | 2.09% |
| Geode Capital Management LLCas of 31 Dec 2023 | 2.66m | 1.91% |
| Baker Bros. Advisors LPas of 31 Dec 2023 | 2.61m | 1.87% |
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Data from 31 Dec 2023 - 31 Dec 2023Source: FactSet Research Systems Inc.
