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About the company
Spyre Therapeutics, Inc. is a biotechnology company. The Company is engaged in creating inflammatory bowel disease (IBD) products by combining antibody engineering, rational therapeutic combinations and precision medicine approaches. Its pipeline includes investigational extended half-life antibodies targeting a4B7, TL1A, and IL-23. Its pipeline programs include SPY003, SPY004, SPY130, and SPY230. It has nominated development candidates for SPY001 and SPY002. Its advanced product candidate, SPY001, is a fully human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4B7 integrin being developed for the treatment of IBD. Its co-lead program, SPY002, has nominated two fully human mAb candidates designed to bind to tumor necrosis factor-like ligand 1A (TL1A), both of which are in preclinical development for the treatment of IBD. SPY003 is a discovery-stage program focused on designing antibodies to bind to Interleukin 23 (IL-23).
- Revenue in USD (TTM)0.00
- Net income in USD-214.90m
- Incorporated2013
- Employees60.00
- LocationSpyre Therapeutics Inc221 Crescent Street, Suite 105WALTHAM 02453United StatesUSA
- Phone+1 (617) 651-5940
- Fax+1 (302) 636-5454
- Websitehttps://spyre.com/
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Peer analysis
Key Information
- Key Information
- Stock Performance
- Per Share Data
- Efficiency
- Management Effectiveness
- Profitability
- Financial Strength
- Growth Rates
| Company | Revenue (TTM) | Net income (TTM) | Market cap | Employees | Price/earnings (TTM) | Price/book value (MRQ) | Price/cash flow (TTM) | Price/sales (TTM) | EPS (excl. extraordinary items, TTM) | EPS (incl. extraordinary items, TTM) | Revenue per share (TTM) | Book value per share (MRQ) | Asset turnover (TTM) | Inventory turnover (TTM) | Receivables turnover (TTM) | Revenues per employee (TTM) | Return on avg assets (TTM) | Return on avg assets (5 yr avg) | Return on investment (TTM) | Return on investment (5 yr avg) | Gross margin (TTM) | Gross margin (5 yr avg) | Net profit margin (TTM) | Net Profit margin (5 yr avg) | Quick ratio (MRQ) | Interest coverage (TTM) | Total debt to capital (MRQ) | Payout ratio (5 yr avg) | Revenue (YOY change %) | Revenue (5 yr growth rate) | Net income (YOY change %) | Net income (5 yr growth rate) | Capital expenditure (5 yr growth rate) | Dividend (5 yr growth rate) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Enliven Therapeutics Inc | 0.00 | -85.21m | 1.24bn | 57.00 | -- | 4.16 | -- | -- | -1.91 | -1.91 | 0.00 | 6.10 | 0.00 | -- | -- | 0.00 | -29.41 | -42.26 | -30.97 | -46.62 | -- | -- | -- | -- | -- | -- | 0.00 | -- | -- | -- | -4,910.75 | -- | -- | -- |
| Maravai Lifesciences Holdings Inc | 276.92m | -224.66m | 1.25bn | 580.00 | -- | 3.63 | -- | 4.52 | -1.65 | -1.65 | 2.04 | 1.37 | 0.1562 | 2.98 | 7.43 | 426,030.80 | -18.23 | 12.67 | -23.39 | 15.46 | 46.36 | 74.79 | -116.68 | 37.32 | 9.94 | -1.47 | 0.4746 | 0.00 | -67.28 | 18.47 | -154.05 | -- | 78.56 | -- |
| Aurinia Pharmaceuticals Inc | 220.36m | -22.55m | 1.26bn | 300.00 | -- | 3.23 | -- | 5.70 | -0.1582 | -0.1582 | 1.53 | 2.71 | 0.3991 | 0.7854 | 5.92 | 734,536.70 | -4.08 | -25.97 | -4.74 | -28.24 | 87.25 | -- | -10.23 | -137.64 | 5.11 | -- | 0.1725 | -- | 30.95 | 227.90 | 27.88 | -- | 57.11 | -- |
| Novavax Inc | 885.19m | -284.86m | 1.29bn | 1.54k | -- | -- | -- | 1.45 | -2.26 | -2.26 | 6.00 | -3.29 | 0.5254 | 8.19 | 8.10 | 573,683.10 | -16.91 | -46.06 | -79.12 | -269.57 | 63.79 | -- | -32.18 | -75.94 | 0.9272 | -17.46 | -- | -- | -50.36 | 95.68 | 17.16 | -- | 108.28 | -- |
| ARS Pharmaceuticals Inc | 2.57m | -49.10m | 1.30bn | 146.00 | -- | 6.47 | -- | 505.09 | -0.5076 | -0.5076 | 0.0266 | 2.07 | 0.011 | -- | -- | 107,000.00 | -21.07 | -20.37 | -22.40 | -21.32 | 76.17 | -- | -1,912.15 | -17,491.75 | 12.52 | -- | 0.00 | -- | -97.72 | -- | -56.75 | -- | -17.18 | -- |
| Arcus Biosciences Inc | 263.00m | -270.00m | 1.31bn | 577.00 | -- | 2.31 | -- | 4.97 | -3.15 | -3.15 | 3.06 | 6.17 | 0.2153 | -- | 6.83 | 455,805.90 | -22.10 | -15.85 | -26.63 | -18.25 | -- | -- | -102.66 | -103.46 | -- | -- | 0.0768 | -- | 4.46 | 69.54 | -14.98 | -- | 45.01 | -- |
| Syndax Pharmaceuticals Inc | 16.00m | -297.06m | 1.33bn | 112.00 | -- | 3.64 | -- | 83.22 | -3.63 | -3.63 | 0.1949 | 4.28 | 0.0388 | -- | 3.60 | 142,857.10 | -72.01 | -27.90 | -81.78 | -30.15 | -- | -- | -1,856.64 | -324.34 | -- | -- | 0.00003 | -- | -- | -- | -40.19 | -- | -- | -- |
| Day One Biopharmaceuticals Inc | 101.95m | -84.29m | 1.35bn | 174.00 | -- | 2.42 | -- | 13.20 | -1.02 | -1.02 | 1.14 | 5.51 | 0.2009 | -- | -- | 657,761.30 | -16.61 | -- | -17.73 | -- | 97.75 | -- | -82.68 | -- | 14.55 | -- | 0.00 | -- | -- | -- | -32.87 | -- | -- | -- |
| MiMedx Group Inc | 342.81m | 90.79m | 1.35bn | 895.00 | 18.59 | 7.49 | 13.61 | 3.95 | 0.4961 | 0.4601 | 2.00 | 1.23 | 1.58 | 2.63 | 6.65 | 383,022.30 | 44.93 | -4.14 | 56.00 | -5.90 | 83.37 | 83.61 | 28.37 | -2.70 | 3.53 | 22.35 | 0.0951 | -- | 20.03 | -2.19 | 310.29 | -- | -26.47 | -- |
| Praxis Precision Medicines Inc | 1.61m | -151.02m | 1.36bn | 82.00 | -- | 3.40 | -- | 848.40 | -10.29 | -10.29 | 0.1058 | 21.52 | 0.0061 | -- | -- | 19,573.17 | -57.75 | -74.04 | -63.81 | -85.12 | -- | -- | -9,409.22 | -24,589.25 | -- | -- | 0.00 | -- | -- | -- | 42.40 | -- | -4.52 | -- |
| Spyre Therapeutics Inc | 0.00 | -214.90m | 1.39bn | 60.00 | -- | 8.09 | -- | -- | -7.44 | -7.44 | 0.00 | 6.37 | 0.00 | -- | -- | 0.00 | -68.40 | -101.87 | -81.72 | -118.83 | -- | -- | -- | -2,949.59 | -- | -- | 0.00 | -- | -61.96 | -25.61 | -304.21 | -- | -- | -- |
| Bicycle Therapeutics PLC (ADR) | 36.90m | -166.28m | 1.40bn | 284.00 | -- | 1.68 | -- | 37.91 | -3.28 | -3.28 | 0.7163 | 12.04 | 0.0451 | -- | 0.9806 | 129,922.50 | -20.33 | -29.45 | -22.03 | -32.98 | -- | -- | -450.64 | -571.36 | -- | -- | 0.0002 | -- | 86.52 | 30.47 | -60.28 | -- | 19.82 | -- |
| Intellia Therapeutics Inc | 43.09m | -522.28m | 1.40bn | 526.00 | -- | 1.46 | -- | 32.53 | -5.45 | -5.45 | 0.4509 | 9.46 | 0.0357 | -- | 5.62 | 81,912.55 | -43.22 | -31.34 | -47.07 | -34.53 | -- | -- | -1,212.19 | -654.71 | -- | -- | 0.00 | -- | -30.40 | 3.57 | -1.48 | -- | 17.08 | -- |
| Cassava Sciences Inc | 0.00 | -17.66m | 1.54bn | 29.00 | -- | 9.26 | -- | -- | -0.3772 | -0.3772 | 0.00 | 3.47 | 0.00 | -- | -- | 0.00 | -8.91 | -30.74 | -10.98 | -32.12 | -- | -- | -- | -- | -- | -- | 0.00 | -- | -- | -- | -27.50 | -- | -- | -- |
| Neumora Therapeutics Inc | 0.00 | -293.70m | 1.55bn | 108.00 | -- | 4.85 | -- | -- | -1.77 | -1.77 | 0.00 | 2.00 | 0.00 | -- | -- | 0.00 | -65.46 | -- | -70.23 | -- | -- | -- | -- | -- | -- | -- | 0.00 | -- | -- | -- | -80.23 | -- | -- | -- |
Data as of Nov 21 2024. Currency figures normalised to Spyre Therapeutics Inc's reporting currency: US Dollar USD
57.11%Per cent of shares held by top holders
| Holder | Shares | % Held |
|---|---|---|
| Fidelity Management & Research Co. LLCas of 30 Sep 2024 | 6.95m | 13.66% |
| Fairmount Funds Management LLCas of 30 Sep 2024 | 4.02m | 7.89% |
| RTW Investments LPas of 30 Sep 2024 | 3.26m | 6.40% |
| Perceptive Advisors LLCas of 30 Sep 2024 | 2.87m | 5.64% |
| The Vanguard Group, Inc.as of 30 Sep 2024 | 2.46m | 4.82% |
| BlackRock Fund Advisorsas of 30 Sep 2024 | 2.43m | 4.78% |
| Braidwell LPas of 30 Sep 2024 | 2.19m | 4.30% |
| Commodore Capital LPas of 30 Sep 2024 | 1.99m | 3.90% |
| SSgA Funds Management, Inc.as of 30 Sep 2024 | 1.54m | 3.03% |
| Wellington Management Co. LLPas of 30 Sep 2024 | 1.37m | 2.69% |
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Data from 30 Sep 2024 - 30 Sep 2024Source: FactSet Research Systems Inc.
