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About the company
Spyre Therapeutics, Inc. is a biotechnology company. The Company is engaged in creating inflammatory bowel disease (IBD) products by combining antibody engineering, rational therapeutic combinations and precision medicine approaches. Its pipeline includes investigational extended half-life antibodies targeting a4B7, TL1A, and IL-23. Its pipeline programs include SPY003, SPY004, SPY130, and SPY230. It has nominated development candidates for SPY001 and SPY002. Its advanced product candidate, SPY001, is a fully human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4B7 integrin being developed for the treatment of IBD. Its co-lead program, SPY002, has nominated two fully human mAb candidates designed to bind to tumor necrosis factor-like ligand 1A (TL1A), both of which are in preclinical development for the treatment of IBD. SPY003 is a discovery-stage program focused on designing antibodies to bind to Interleukin 23 (IL-23).
- Revenue in USD (TTM)688.00k
- Net income in USD-364.23m
- Incorporated2013
- Employees30.00
- LocationSpyre Therapeutics Inc221 Crescent Street, Suite 105WALTHAM 02453United StatesUSA
- Phone+1 (617) 651-5940
- Fax+1 (302) 636-5454
- Websitehttps://spyre.com/
Peer analysis
- Key Information
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Company | Revenue (TTM) | Net income (TTM) | Market cap | Employees | Price/earnings (TTM) | Price/book value (MRQ) | Price/cash flow (TTM) | Price/sales (TTM) | EPS (excl. extraordinary items, TTM) | EPS (incl. extraordinary items, TTM) | Revenue per share (TTM) | Book value per share (MRQ) | Asset turnover (TTM) | Inventory turnover (TTM) | Receivables turnover (TTM) | Revenues per employee (TTM) | Return on avg assets (TTM) | Return on avg assets (5 yr avg) | Return on investment (TTM) | Return on investment (5 yr avg) | Gross margin (TTM) | Gross margin (5 yr avg) | Net profit margin (TTM) | Net Profit margin (5 yr avg) | Quick ratio (MRQ) | Interest coverage (TTM) | Total debt to capital (MRQ) | Payout ratio (5 yr avg) | Revenue (YOY change %) | Revenue (5 yr growth rate) | Net income (YOY change %) | Net income (5 yr growth rate) | Capital expenditure (5 yr growth rate) | Dividend (5 yr growth rate) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Day One Biopharmaceuticals Inc | 0.00 | -208.94m | 1.40bn | 174.00 | -- | 4.72 | -- | -- | -2.50 | -2.50 | 0.00 | 3.40 | 0.00 | -- | -- | 0.00 | -64.27 | -- | -69.93 | -- | -- | -- | -- | -- | -- | -- | 0.00 | -- | -- | -- | -32.87 | -- | -- | -- |
Nurix Therapeutics Inc | 62.30m | -165.00m | 1.41bn | 284.00 | -- | 3.81 | -- | 22.68 | -2.92 | -2.92 | 1.10 | 5.76 | 0.1446 | -- | -- | 219,376.80 | -38.30 | -33.01 | -46.57 | -39.66 | -- | -- | -264.84 | -260.65 | -- | -- | 0.00 | -- | 99.31 | 15.50 | 20.19 | -- | 39.42 | -- |
Sana Biotechnology Inc | 0.00 | -308.61m | 1.42bn | 328.00 | -- | 3.78 | -- | -- | -1.53 | -1.53 | 0.00 | 1.70 | 0.00 | -- | -- | 0.00 | -43.21 | -38.99 | -48.50 | -42.70 | -- | -- | -- | -- | -- | -- | 0.00 | -- | -- | -- | -5.11 | -- | 112.71 | -- |
Arcus Biosciences Inc | 237.00m | -231.00m | 1.44bn | 577.00 | -- | 2.03 | -- | 6.07 | -3.10 | -3.10 | 3.07 | 7.78 | 0.1861 | -- | 6.24 | 410,745.20 | -18.14 | -15.85 | -21.35 | -18.25 | -- | -- | -97.47 | -103.46 | -- | -- | 0.00 | -- | 4.46 | 69.54 | -14.98 | -- | 45.01 | -- |
Longboard Pharmaceuticals Inc | 0.00 | -57.95m | 1.45bn | 50.00 | -- | 4.64 | -- | -- | -2.25 | -2.25 | 0.00 | 8.07 | 0.00 | -- | -- | 0.00 | -28.45 | -- | -29.73 | -- | -- | -- | -- | -- | -- | -- | 0.00 | -- | -- | -- | -23.84 | -- | -- | -- |
Vir Biotechnology Inc | 79.60m | -539.44m | 1.46bn | 587.00 | -- | 0.9394 | -- | 18.29 | -4.01 | -4.01 | 0.5916 | 11.39 | 0.0357 | -- | -- | 135,603.10 | -24.19 | -0.6081 | -27.80 | -0.7192 | 98.85 | -- | -677.69 | -1.53 | -- | -- | 0.00 | -- | -94.67 | 51.87 | -219.24 | -- | 16.77 | -- |
Belite Bio Inc (ADR) | 0.00 | -32.61m | 1.49bn | 20.00 | -- | 15.18 | -- | -- | -1.18 | -1.18 | 0.00 | 3.24 | 0.00 | -- | -- | 0.00 | -46.26 | -- | -46.26 | -- | -- | -- | -- | -- | -- | -- | 0.00 | -- | -- | -- | -150.09 | -- | -- | -- |
Dynavax Technologies Corp | 236.15m | 9.22m | 1.52bn | 408.00 | 232.43 | 2.46 | 111.13 | 6.44 | 0.05 | 0.05 | 1.67 | 4.73 | 0.2414 | 0.7769 | 3.24 | 578,796.60 | 0.9427 | 4.16 | 1.02 | 5.71 | 80.34 | 64.83 | 3.91 | 9.19 | 14.10 | -- | 0.265 | 0.00 | -67.86 | 95.19 | -102.18 | -- | -23.03 | -- |
MannKind Corp | 224.60m | 8.49m | 1.59bn | 414.00 | 249.68 | -- | 118.44 | 7.09 | 0.0234 | 0.0234 | 0.7589 | -0.8492 | 0.5766 | 2.69 | 11.34 | 542,509.70 | 2.18 | -26.07 | 2.84 | -37.80 | 70.99 | 59.68 | 3.78 | -57.61 | 3.57 | 1.50 | 1.80 | -- | 99.42 | 48.17 | 86.34 | -- | 160.47 | -- |
Spyre Therapeutics Inc | 688.00k | -364.23m | 1.60bn | 30.00 | -- | -- | -- | 2,322.85 | -71.35 | -71.35 | 0.0456 | 11.08 | 0.0026 | -- | -- | 22,933.33 | -134.88 | -101.87 | -150.32 | -118.83 | -- | -- | -52,939.68 | -2,949.59 | -- | -- | 0.00 | -- | -61.96 | -25.61 | -304.21 | -- | -- | -- |
Kura Oncology Inc | 0.00 | -168.09m | 1.61bn | 142.00 | -- | 3.18 | -- | -- | -2.18 | -2.18 | 0.00 | 6.63 | 0.00 | -- | -- | 0.00 | -34.31 | -26.04 | -36.21 | -27.45 | -- | -- | -- | -- | -- | -- | 0.0182 | -- | -- | -- | -12.36 | -- | -- | -- |
BioCryst Pharmaceuticals Inc | 355.40m | -208.59m | 1.62bn | 536.00 | -- | -- | -- | 4.56 | -1.07 | -1.07 | 1.81 | -2.31 | 0.727 | 0.1787 | 6.51 | 663,050.40 | -42.67 | -47.95 | -54.00 | -64.89 | 98.56 | 97.06 | -58.69 | -114.94 | 3.48 | -1.00 | 2.30 | -- | 22.37 | 74.21 | 8.33 | -- | 42.73 | -- |
Soleno Therapeutics Inc | 0.00 | -52.03m | 1.68bn | 33.00 | -- | 11.27 | -- | -- | -2.68 | -2.68 | 0.00 | 4.30 | 0.00 | -- | -- | 0.00 | -55.24 | -53.90 | -62.26 | -61.85 | -- | -- | -- | -- | -- | -- | 0.00 | -- | -- | -- | -62.00 | -- | -- | -- |
Edgewise Therapeutics Inc | 0.00 | -105.85m | 1.77bn | 92.00 | -- | 3.31 | -- | -- | -1.53 | -1.53 | 0.00 | 5.73 | 0.00 | -- | -- | 0.00 | -23.52 | -- | -24.25 | -- | -- | -- | -- | -- | -- | -- | 0.00 | -- | -- | -- | -48.08 | -- | -- | -- |
Holder | Shares | % Held |
---|---|---|
Fidelity Management & Research Co. LLCas of 31 Mar 2024 | 6.33m | 12.46% |
Fairmount Funds Management LLCas of 14 May 2024 | 4.02m | 7.91% |
Perceptive Advisors LLCas of 31 Mar 2024 | 2.56m | 5.04% |
RTW Investments LPas of 31 Mar 2024 | 2.23m | 4.40% |
Commodore Capital LPas of 31 Mar 2024 | 1.88m | 3.71% |
Avoro Capital Advisor LLCas of 31 Mar 2024 | 1.84m | 3.62% |
Deep Track Capital LPas of 31 Mar 2024 | 1.21m | 2.39% |
Adage Capital Management LPas of 31 Mar 2024 | 1.11m | 2.18% |
Wellington Management Co. LLPas of 31 Mar 2024 | 753.07k | 1.48% |
Franklin Advisers, Inc.as of 31 Mar 2024 | 741.90k | 1.46% |