Profile data is unavailable for this security.
About the company
Spyre Therapeutics, Inc. is a biotechnology company. The Company is engaged in creating inflammatory bowel disease (IBD) products by combining antibody engineering, rational therapeutic combinations and precision medicine approaches. Its pipeline includes investigational extended half-life antibodies targeting a4B7, TL1A, and IL-23. Its pipeline programs include SPY003, SPY004, SPY130, and SPY230. It has nominated development candidates for SPY001 and SPY002. Its advanced product candidate, SPY001, is a fully human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4B7 integrin being developed for the treatment of IBD. Its co-lead program, SPY002, has nominated two fully human mAb candidates designed to bind to tumor necrosis factor-like ligand 1A (TL1A), both of which are in preclinical development for the treatment of IBD. SPY003 is a discovery-stage program focused on designing antibodies to bind to Interleukin 23 (IL-23).
- Revenue in USD (TTM)688.00k
- Net income in USD-364.23m
- Incorporated2013
- Employees30.00
- LocationSpyre Therapeutics Inc221 Crescent Street, Suite 105WALTHAM 02453United StatesUSA
- Phone+1 (617) 651-5940
- Fax+1 (302) 636-5454
- Websitehttps://spyre.com/
Mergers & acquisitions
Acquired company | SYRE:NSQ since announced | Transaction value |
---|---|---|
Spyre Therapeutics Inc | 1,321.05% | 1.42m |
Peer analysis
- Key Information
- Stock Performance
- Per Share Data
- Efficiency
- Management Effectiveness
- Profitability
- Financial Strength
- Growth Rates
Company | Revenue (TTM) | Net income (TTM) | Market cap | Employees | Price/earnings (TTM) | Price/book value (MRQ) | Price/cash flow (TTM) | Price/sales (TTM) | EPS (excl. extraordinary items, TTM) | EPS (incl. extraordinary items, TTM) | Revenue per share (TTM) | Book value per share (MRQ) | Asset turnover (TTM) | Inventory turnover (TTM) | Receivables turnover (TTM) | Revenues per employee (TTM) | Return on avg assets (TTM) | Return on avg assets (5 yr avg) | Return on investment (TTM) | Return on investment (5 yr avg) | Gross margin (TTM) | Gross margin (5 yr avg) | Net profit margin (TTM) | Net Profit margin (5 yr avg) | Quick ratio (MRQ) | Interest coverage (TTM) | Total debt to capital (MRQ) | Payout ratio (5 yr avg) | Revenue (YOY change %) | Revenue (5 yr growth rate) | Net income (YOY change %) | Net income (5 yr growth rate) | Capital expenditure (5 yr growth rate) | Dividend (5 yr growth rate) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Kiniksa Pharmaceuticals Ltd | 301.77m | 8.65m | 1.40bn | 297.00 | 232.04 | 3.24 | 129.13 | 4.65 | 0.0852 | 0.0852 | 4.16 | 6.10 | 0.627 | 1.46 | 25.77 | 1,016,067.00 | 1.80 | -16.49 | 2.01 | -18.72 | 87.75 | -- | 2.87 | -53.64 | 3.79 | -- | 0.00 | -- | 22.74 | -- | -92.32 | -- | -52.35 | -- |
Day One Biopharmaceuticals Inc | 0.00 | -208.94m | 1.41bn | 174.00 | -- | 4.76 | -- | -- | -2.50 | -2.50 | 0.00 | 3.40 | 0.00 | -- | -- | 0.00 | -64.27 | -- | -69.93 | -- | -- | -- | -- | -- | -- | -- | 0.00 | -- | -- | -- | -32.87 | -- | -- | -- |
Xencor Inc | 162.18m | -133.36m | 1.42bn | 280.00 | -- | 2.32 | -- | 8.76 | -2.19 | -2.19 | 2.68 | 9.94 | 0.1922 | -- | 11.02 | 579,217.90 | -15.90 | -3.70 | -17.39 | -4.12 | -- | -- | -82.74 | -15.92 | -- | -- | 0.0323 | -- | 2.28 | 32.90 | -128.50 | -- | 18.36 | -- |
Pacira Biosciences Inc | 681.75m | 70.47m | 1.43bn | 711.00 | 23.78 | 1.61 | 9.90 | 2.10 | 1.30 | 1.30 | 12.11 | 19.18 | 0.4389 | 1.93 | 7.00 | 958,866.40 | 4.54 | 3.35 | 4.84 | 3.98 | 73.15 | 72.63 | 10.34 | 8.57 | 4.78 | 51.11 | 0.3684 | 0.00 | 1.22 | 14.88 | 163.72 | -- | 0.8761 | -- |
Tarsus Pharmaceuticals Inc | 42.56m | -148.21m | 1.44bn | 244.00 | -- | 5.25 | -- | 33.95 | -4.72 | -4.72 | 1.35 | 7.29 | 0.1519 | -- | 2.63 | 174,430.30 | -52.88 | -31.56 | -58.73 | -33.82 | 92.37 | -- | -348.22 | -242.59 | 7.92 | -- | 0.0981 | -- | -32.42 | -- | -118.86 | -- | 279.39 | -- |
Dynavax Technologies Corp | 236.15m | 9.22m | 1.45bn | 408.00 | 222.42 | 2.35 | 106.34 | 6.16 | 0.05 | 0.05 | 1.67 | 4.73 | 0.2414 | 0.7769 | 3.24 | 578,796.60 | 0.9427 | 4.16 | 1.02 | 5.71 | 80.34 | 64.83 | 3.91 | 9.19 | 14.10 | -- | 0.265 | 0.00 | -67.86 | 95.19 | -102.18 | -- | -23.03 | -- |
Morphic Holding Inc | 0.00 | -161.25m | 1.46bn | 124.00 | -- | 2.21 | -- | -- | -3.49 | -3.49 | 0.00 | 13.25 | 0.00 | -- | -- | 0.00 | -28.67 | -22.69 | -29.49 | -24.99 | -- | -- | -- | -258.10 | -- | -- | 0.00 | -- | -99.26 | -31.11 | -157.61 | -- | 13.50 | -- |
Avadel Pharmaceuticals PLC (ADR) | 55.14m | -156.83m | 1.49bn | 154.00 | -- | 18.99 | -- | 27.00 | -1.86 | -1.86 | 0.6334 | 0.8157 | 0.3573 | -- | 4.80 | 358,058.40 | -101.63 | -40.21 | -172.85 | -47.99 | 95.71 | -- | -284.42 | -374.75 | 2.60 | -14.71 | 0.00 | -- | -- | -22.99 | -16.59 | -- | -- | -- |
Spyre Therapeutics Inc | 688.00k | -364.23m | 1.52bn | 30.00 | -- | -- | -- | 2,213.25 | -71.35 | -71.35 | 0.0456 | 11.08 | 0.0026 | -- | -- | 22,933.33 | -134.88 | -101.87 | -150.32 | -118.83 | -- | -- | -52,939.68 | -2,949.59 | -- | -- | 0.00 | -- | -61.96 | -25.61 | -304.21 | -- | -- | -- |
Arcus Biosciences Inc | 237.00m | -231.00m | 1.54bn | 577.00 | -- | 2.17 | -- | 6.49 | -3.10 | -3.10 | 3.07 | 7.78 | 0.1861 | -- | 6.24 | 410,745.20 | -18.14 | -15.85 | -21.35 | -18.25 | -- | -- | -97.47 | -103.46 | -- | -- | 0.00 | -- | 4.46 | 69.54 | -14.98 | -- | 45.01 | -- |
Neumora Therapeutics Inc | 0.00 | -254.02m | 1.54bn | 120.00 | -- | 3.63 | -- | -- | -2.44 | -2.44 | 0.00 | 2.66 | 0.00 | -- | -- | 0.00 | -60.32 | -- | -63.83 | -- | -- | -- | -- | -- | -- | -- | 0.00 | -- | -- | -- | -80.23 | -- | -- | -- |
Ligand Pharmaceuticals Inc | 118.31m | 96.34m | 1.55bn | 58.00 | 16.44 | 1.91 | 11.70 | 13.07 | 5.23 | 5.23 | 6.52 | 45.00 | 0.1372 | 0.5475 | 4.11 | 2,039,879.00 | 11.17 | 12.32 | 11.98 | 12.99 | 91.82 | 81.65 | 81.43 | 80.32 | 19.51 | -- | 0.00 | -- | -33.09 | -12.18 | 1,131.21 | -17.86 | 42.63 | -- |
Taro Pharmaceutical Industries Ltd | 610.83m | 45.70m | 1.59bn | 1.55k | 34.79 | 0.8937 | 20.03 | 2.60 | 1.22 | 1.22 | 16.25 | 47.33 | 0.2854 | 1.45 | 2.76 | 393,068.20 | 2.14 | 1.85 | 2.59 | 2.21 | 48.02 | 56.82 | 7.48 | 6.99 | 3.03 | -- | 0.00 | 0.00 | 2.07 | -2.85 | -56.33 | -34.53 | -7.64 | -- |
Tilray Brands Inc | 743.25m | -351.95m | 1.60bn | 1.60k | -- | 0.4563 | -- | 2.15 | -0.4979 | -0.4979 | 1.04 | 4.34 | 0.1731 | 2.39 | 8.85 | 464,530.00 | -7.61 | -- | -8.38 | -- | 28.01 | -- | -43.98 | -- | 1.18 | 0.2252 | 0.1216 | -- | -0.1986 | -- | -204.67 | -- | -- | -- |
Supernus Pharmaceuticals Inc | 597.40m | -15.51m | 1.60bn | 652.00 | -- | 1.72 | 23.00 | 2.68 | -0.2843 | -0.2843 | 10.86 | 16.90 | 0.3859 | 0.922 | 4.10 | 916,259.20 | -1.00 | 4.95 | -1.51 | 6.41 | 87.17 | 88.61 | -2.60 | 12.84 | 1.49 | -- | 0.00 | -- | -8.95 | 8.24 | -97.83 | -58.81 | -8.17 | -- |
Soleno Therapeutics Inc | 0.00 | -52.03m | 1.60bn | 33.00 | -- | 10.73 | -- | -- | -2.68 | -2.68 | 0.00 | 4.30 | 0.00 | -- | -- | 0.00 | -55.24 | -53.90 | -62.26 | -61.85 | -- | -- | -- | -- | -- | -- | 0.00 | -- | -- | -- | -62.00 | -- | -- | -- |
Holder | Shares | % Held |
---|---|---|
Fidelity Management & Research Co. LLCas of 31 Mar 2024 | 6.33m | 17.50% |
Fairmount Funds Management LLCas of 14 May 2024 | 4.02m | 11.12% |
Perceptive Advisors LLCas of 31 Mar 2024 | 2.56m | 7.07% |
RTW Investments LPas of 31 Mar 2024 | 2.23m | 6.18% |
Commodore Capital LPas of 31 Mar 2024 | 1.88m | 5.21% |
Avoro Capital Advisor LLCas of 31 Mar 2024 | 1.84m | 5.09% |
Deep Track Capital LPas of 31 Mar 2024 | 1.21m | 3.36% |
Adage Capital Management LPas of 31 Mar 2024 | 1.11m | 3.06% |
Wellington Management Co. LLPas of 31 Mar 2024 | 812.86k | 2.25% |
Franklin Advisers, Inc.as of 31 Mar 2024 | 741.90k | 2.05% |